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ProteomicsTORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes
Target of rapamycin complex 1 (TORC1) promotes biogenesis and inhibits degradation of ribosomes in response to nutrient availability. To ensure a basal supply of ribosomes, cells preserve a small pool of dormant ribosomes under nutrient-limited conditions. The regulation of dormant ribosomes is poor...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2023-01-19 | PXD037117 | Pride
Protein synthesis Dormant ribosome Proteasome Torc1 Ribosome preservation factor Ribophagy 
ProteomicsA molecular network of conserved factors keeps ribosomes dormant in the egg
Ribosomes are produced in large quantities during oogenesis and stored in the egg. However, the egg and early embryo are translationally inactive. How translation is activated during embryogenesis is poorly understood. Using mass-spectrometry and cryo-EM analyses of ribosomes isolated from zebrafish...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Xenopus laevis (African clawed frog) 
2022-11-03 | PXD026866 | Pride
Cryo-em Cross-linking Xenopus Mass-spectrometry Ribosome Zebrafish 
TranscriptomicsPseudomonas aeruginosa biofilm cells contain ribosome hibernation factors in the dormant antibiotic-tolerant subpopulation
Bacteria growing in biofilms are physiologically heterogeneous, due in part to their adaptation to local environmental conditions. Here, we characterized the local transcriptional responses of Pseudomonas aeruginosa growing in biofilms by using microarray analysis of isolated biofilm subpopulations....
ORGANISM(S): Pseudomonas aeruginosa 
2012-05-02 | E-GEOD-34762 | biostudies-arrayexpress
ProteomicsEvolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome
Microsporidia are eukaryotic parasites that infect essentially all animal species, including many of agricultural importance, and are significant opportunistic parasites of humans. They are characterized by having a specialized infection apparatus, an obligate intracellular lifestyle, rudimentary mi...
ORGANISM(S): Vairimorpha necatrix 
2019-07-02 | PXD013432 | Pride
Cryo-em Vairimorpha necatrix Mass spectrometry Ribosome Microsporidia 
UnknownTORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes.
Not available
S-EPMC9975950 | biostudies-literature
UnknownA molecular network of conserved factors keeps ribosomes dormant in the egg.
Not available
S-EPMC7614339 | biostudies-literature
UnknownEvolutionary compaction and adaptation visualized by the structure of the dormant microsporidian ribosome.
Not available
S-EPMC6814508 | biostudies-literature
UnknownDormant non-culturable Mycobacterium tuberculosis retains stable low-abundant mRNA.
Not available
S-EPMC4647672 | biostudies-literature
UnknownTORC1 phosphorylates and inhibits the ribosome preservation factor Stm1 to activate dormant ribosomes
Not available
S-SCDT-10_15252-EMBJ_2022112344 | biostudies-other
TranscriptomicsDormant and after-ripened seeds are distinguished by early transcriptional differences in the imbibed state
We analyzed the transcriptome of dormant and after-ripened imbibed seeds of the Arabidopsis accession Cape verde Islands. We analyzed the transcriptional changes in temporal and spatial detail by sampling at four imbibition time-points (3, 7, 12 and 24 hours after sowing) and two seed compartments (...
ORGANISM(S): Arabidopsis thaliana 
2016-08-24 | E-GEOD-76907 | biostudies-arrayexpress
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