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MetabolomicsMetabolomic Profiling of the Striatum in Shank3 Knockout ASD Rats: Effects of Early Swimming Regulation

OBJECTIVE: This study aimed to investigate the regulatory impact of early swimming intervention on striatal metabolism in Shank3 gene knockout ASD model rats.

METHODS: Shank3 gene knockout exon 11-21 male 8-day-old SD rats were used as experimental subject...

2024-09-27 | MTBLS8577 | MetaboLights
TranscriptomicsTranscriptome profiling of the human dorsal striatum in bipolar disorder
Bipolar disorder (BD) is a highly heritable and heterogeneous mental illness whose manifestations often include impulsive and risk-taking behavior. This particular phenotype suggests that abnormal striatal function could be involved in BD etiology, yet most transcriptomic studies of this disorder ha...
ORGANISM(S): Homo sapiens 
2016-08-10 | E-GEOD-80336 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse brain region bed nucleus of the stria terminalis, nucleus accumbens, and dorsal striatum to identify distinct transcriptional patterns.
To identify distinct transcriptional patterns between the major subcortical dopamine targets commonly studied in addiction we studied differences in gene expression between the bed nucleus of the stria terminalis (BNST), nucleus accumbens (NAc), and dorsal striatum (dStr) using microarray analysis. ...
ORGANISM(S): Mus musculus 
2007-11-13 | E-GEOD-5763 | biostudies-arrayexpress
ProteomicsProteomics of rat overexpressing human DISC1 in the dorsal striatum
Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression. A transgenic rat modestly overexpressing non-mutant human DISC1, modeling aberrant proteostasis of the DISC1 protein, displays behavioral...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-02-27 | PXD008123 | Pride
Synapse Disc1 Synaptosome Human 
TranscriptomicsLoss of MeCP2 function is associated with distinct gene expression changes in the striatum
Rett syndrome (RTT) is a neurodevelopmental disorder characterized by developmental regression around 6-18 months after birth, followed by a lifetime of intellectual disability, stereotyped behaviors, and motor deficits. RTT is caused by mutations in MeCP2, a methyl-CpG binding protein that was trad...
ORGANISM(S): Mus musculus 
2013-07-13 | E-GEOD-42895 | biostudies-arrayexpress
ProteomicsMulti-epitope immunocapture of huntingtin reveals striatum-selective molecular signatures in Huntington's disease mouse models
Huntington's disease (HD) is a debilitating progressive neurodegenerative disorder that has profound effects on an individual's cognitive, motor, and behavioral functions. HD is caused by mutation in the huntingtin (HTT) gene that results in CAG repeat expansion and production of an aggregation-pron...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
2024-04-10 | MSV000094509 | MassIVE
TranscriptomicsTranscription profiling of mouse wild type and Ctip2-/- (Bcl11b) mutant striatum at P0
Striatal medium spiny neurons (MSN) are critically involved in motor control, and their degeneration is a principal component of Huntington’s disease. We find that the transcription factor Ctip2 (also known as Bcl11b) is central to MSN differentiation and striatal development. Within the striatum,...
ORGANISM(S): Mus musculus 
2008-06-16 | E-GEOD-9330 | biostudies-arrayexpress
TranscriptomicsRNA-seq of learning and control mice (Mus musculus) striatum across three temporal phases of learning
To understand the effects of learning on expression in mouse striatum, we combined an automated operant conditioning chamber (OCC) setup with an efficient RNA-sequencing protocol. We compared 450 striatal expression profiles from 75 mice, e.g., the data contains 6 samples per mouse. Biopsies were ta...
ORGANISM(S): Mus musculus 
2025-10-25 | E-MTAB-15694 | biostudies-arrayexpress
ProteomicsProteomics analysis of dorsal striatum reveals changes in synaptosomal proteins following ethamphetamine self-administration in rats
Methamphetamine is a widely abused, highly addictive drug. Regulation of synaptic proteins within the brain’s reward pathway modulates addiction behaviours, the progression of drug addiction and long-term changes in brain structure and function that result from drug use. Therefore, using large scale...
ORGANISM(S): Oryctolagus cuniculus (Rabbit) 
2015-05-06 | PXD001443 | Pride
Lc-ms/ms Rat Shotgun proteomics Synaptosome 
TranscriptomicsRNA-Sequencing from ventral mid brain and striatum of paraquat, pyridaben and paraquat+maneb mice models of Parkinson's disease.
We report RNA-sequencing from ventral mid brain and striatum from paraquat, pyridaben and paraquat+maneb mice models of Parkinson's disease. We observed several differentially expressed genes upon pesticide exposure which we analyzed by pathway analysis. We examined 3 replicates each for ventral mid...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-36232 | biostudies-arrayexpress
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