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TranscriptomicsTranscriptome profiling of human neural progenitor cells and neurons with DISC1 interruption
Purpose: Genetic and clinical association studies have identified disrupted-in-schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is interrupted by a balanced chr(1;11) translocation in a Scottish family, in which the translocation predisposes to psychiatric disorders. ...
ORGANISM(S): Homo sapiens 
2015-09-14 | E-GEOD-71289 | biostudies-arrayexpress
ProteomicsProteomics of rat overexpressing human DISC1 in the dorsal striatum
Disrupted-in-schizophrenia 1 (DISC1) is a key protein involved in behavioral processes and various mental disorders, including schizophrenia and major depression. A transgenic rat modestly overexpressing non-mutant human DISC1, modeling aberrant proteostasis of the DISC1 protein, displays behavioral...
ORGANISM(S): Homo sapiens (Human) Rattus norvegicus (Rat) 
2018-02-27 | PXD008123 | Pride
Synapse Disc1 Synaptosome Human 
ProteomicsHuman Neuron Proteome Altered by Disrupted in schizophrenia 1 (DISC1) Mutations
Disrupted in schizophrenia 1 is a protein that is encoded by the DISC1 gene in humans. In coordination with a wide array of interacting partners, DISC1 has been shown to participate in the regulation of cell proliferation, differentiation, migration, neuronal axon and dendrite outgrowth, synapse for...
ORGANISM(S): Homo sapiens (Human) 
2021-09-08 | PXD013391 | Pride
Psychiatric disorders  schizophrenia  major depression  disc1  proteomics  proteome 
ProteomicsEndogenous Cell Type-Specific DISC1 Interactomes Reveal Protein Networks Associated to Neurodevelopmental Disorders
Disrupted in schizophrenia 1 (DISC1) has been implicated in contributing to a number of psychiatric diseases and neurodevelopmental phenotypes such as the proliferation and differentiation of neural progenitor cells. While there has been significant effort directed towards understanding the function...
ORGANISM(S): Homo sapiens (Human) 
2018-07-04 | PXD007103 | Pride
Disc1 Neural Neural progenitor 
TranscriptomicsTranscriptional consequences of DISC1 knockdown in human neural progenitor cells
Background: One of the strongest identified risk factors for major psychiatric illness is a chromosomal translocation directly disrupting the DISC1 gene, which is observed in members of a large Scottish family. Although DISC1 is known to function through a variety of molecular pathways, no global as...
ORGANISM(S): Homo sapiens 
2016-03-01 | E-GEOD-35548 | biostudies-arrayexpress
GenomicsRNA-seq of oligodendroglia progenitor cells(OPCs) isolated from WT and DISC1-Δ3 mice
RNA-seq of oligodendroglia progenitor cells(OPCs) isolated from WT and DISC1-Δ3 mice
PRJNA760316 | ENA
GenomicsDISC1 Protects Against Zika Virus Infection and Long-Term Neurological Damage Through AMPK-mTOR-Mediated Autophagy
DISC1 Protects Against Zika Virus Infection and Long-Term Neurological Damage Through AMPK-mTOR-Mediated Autophagy
PRJNA1222827 | ENA
TranscriptomicsTranscriptome profiling of human neural progenitor cells and neurons with DISC1 interruption
Purpose: Genetic and clinical association studies have identified disrupted-in-schizophrenia 1 (DISC1) as a candidate risk gene for major mental illness. DISC1 is interrupted by a balanced chr(1;11) translocation in a Scottish family, in which the translocation predisposes to psychiatric disorders. ...
ORGANISM(S): Homo sapiens 
2015-09-14 | GSE71289 | GEO
GenomicsDual phosphorylation of DISC1 at Ser58 and Ser713 regulates polarization of cortical neurons via GSK3β
Dual phosphorylation of DISC1 at Ser58 and Ser713 regulates polarization of cortical neurons via GSK3β
PRJNA962027 | ENA
TranscriptomicsRNA-seq of oligodendroglia progenitor cells(OPCs) isolated from WT and DISC1-Δ3 mice
Disrupted-in-schizophrenia-1 (DISC1), as one of the schizophrenia susceptibility genes highly expressed in oligodendrocyte precursor cells (OPCs), impacts oligodendroglial differentiation and myelination. Several DISC1 splicing variants, including DISC1-Δ3 (a DISC1 transcript with deleted exon 3 in ...
ORGANISM(S): Mus musculus 
2022-12-28 | GSE183341 | GEO
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