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TranscriptomicsTranscription profiling of human prefrontal cortex during postnatal development
Fresh frozen post mortem prefrontal cortex tissue (Brodman area 46) was obtained from 44 individuals varying in age from 0 to 49 years. RNA was extracted from these samples and hybridized to HG133plus2.0 GeneChips. The data was used to examine patterns of gene expression over the course of human pos...
ORGANISM(S): Homo sapiens 
2009-12-02 | E-GEOD-13564 | biostudies-arrayexpress
TranscriptomicsWhole genome expression in Parkinson disease and neurologically healthy control prefrontal cortex Brodmann area 9 samples
Whole genome expression in Parkinson disease and neurologically healthy control prefrontal cortex Brodmann area 9 samples
ORGANISM(S): Homo sapiens 
2012-09-19 | E-MTAB-812 | biostudies-arrayexpress
TranscriptomicsTemporal Dynamics and Genetic Control of Transcription in the Human Prefrontal Cortex
In order to gain a global molecular perspective on how the human genome gives rise to the brain, we explore the temporal dynamics and genetic control of transcription in human dorsolateral prefrontal cortex in an extensive series of brain tissue from fetal development through aging. We discover a wa...
ORGANISM(S): Homo sapiens 
2011-10-26 | E-GEOD-30272 | biostudies-arrayexpress
GenomicsGenome-wide DNA methylation profiling of human dorsolateral prefrontal cortex
Reduced representation bisulfite sequencing (RRBS) was conducted on dorsolateral prefrontal cortex tissue samples taken from the brains of control individuals not affected by neurological disorder DNA methylation profiling was conducted using RRBS and the Illumina Genome Analyzer IIx
ORGANISM(S): Homo sapiens 
2012-11-29 | E-GEOD-42590 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of the brain transcriptome implicates dysregulation of neuroplasticity, circadian rhythms, and GTPase binding in bipolar disorder
See "Akula et al., Molecular Psychiatry in Press". RNA-sequencing (RNA-seq) is a powerful technique to investigate the complexity of gene expression in the human brain. We used RNA-seq to survey the brain transcriptome in high-quality post-mortem dorsolateral prefrontal cortex from 11 indi...
ORGANISM(S): Homo sapiens 
2014-01-08 | E-GEOD-53239 | biostudies-arrayexpress
ProteomicsQuantitative Proteomics of Dorsolateral Prefrontal Cortex
Autism spectrum disorder (ASD) is a severe neurodevelopmental disorder with a rising prevalence and genetic and environmental etiologies. Symptoms include deficits in social communication, repetitive patterns of behavior, and cognitive impairment. Neuroanatomic and biochemical investigations involve...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD048017 | Pride
Autism  brodmann area 9  childhood  proteomics 
ProteomicsANALYSIS OF NETWORKS IN THE DORSOLATERAL PREFRONTAL CORTEX IN CHRONIC SCHIZOPHRENIA: RELEVANCE OF ALTERED IMMUNE RESPONSE
The dorsolateral prefrontal cortex (DLPFC) is the association area in the anterior part of the frontal lobe and has a crucial role in cognitive functioning and negative symptoms in SZschizophrenia. However, limited information of altered protein networks is available in this region in schizophrenia....
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD024939 | Pride
Human Brain Schizophrenia Prefrontal cortex 
TranscriptomicsTranscription profiling of human adult postmortem brain tissue from subjects with bipolar disorder and healthy controls
This SuperSeries is composed of the following subset Series:; GSE5388: Adult postmortem brain tissue (dorsolateral prefrontal cortex) in subjects with bipolar disorder; GSE5389: Adult postmortem brain tissue (ortibtofrontal cortex) in subjects with bipolar disorder; Bipolar affective disorder is a s...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5392 | biostudies-arrayexpress
TranscriptomicsGene expression changes during primate postnatal brain development
In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. During human evolution sexual maturation has been delayed relative to other primates and this may have played a critical role for both the increase of human brain...
ORGANISM(S): Macaca mulatta 
2009-03-09 | E-GEOD-11512 | biostudies-arrayexpress
TranscriptomicsWhole transcriptome RNA-seq of undiseased human prefrontal cortex
We report the application of high-throughput RNA sequencing to the human prefrontal cortex. The brain dataset was obtained by sequencing total RNAs extracted from the dorsolateral prefrontal cortex of five deceased human patients with no apparent pathology, followed by depletion of ribosomal RNA to ...
ORGANISM(S): Homo sapiens 
2013-07-01 | E-GEOD-46523 | biostudies-arrayexpress
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