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TranscriptomicsMutant K-ras promotes carcinogen-induced murine colorectal tumourigenesis, but does not alter tumour chromosome stability
K-ras mutations are observed in around 40% human colorectal adenomas and carcinomas and contribute to the pathogenesis of human and rodent colorectal tumour formation. Previously, we developed and characterised a strain of transgenic mice with inducible intestinal epithelial expression of K-rasVal12...
ORGANISM(S): Mus musculus 
2010-10-02 | E-GEOD-24010 | biostudies-arrayexpress
MetabolomicsHabitual Coffee Intake Shapes the Gut Microbiome and Modifies Host Physiology and Cognition: double-blind, randomised, parallel design

Coffee influences multiple physiological processes, including gut function, stress, cognition, and the microbiome. However, the mechanisms underlying these effects remain poorly understood. In this study, we examined coffee’s impact on the microbiota–gut–brain axis—a bidirectional communication p...

2026-03-26 | MTBLS13401 | MetaboLights
TranscriptomicsTranscriptomic changes induced in yeast cells by the lack of potassium in the medium
Potassium is the major intracellular cation in S. cerevisiae, which can be concentrated up to 200-300 mM even from relatively low potassium (< 1 mM) environments. This is achieved by mean of a high affinity K+-transport system encoded by the genes TRK1 and TRK2. Recently, our group became interested...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-13 | E-GEOD-24712 | biostudies-arrayexpress
MetabolomicsIdentification of BolA protein reveals a novel virulence factor in Klebsiella pneumoniae that contributes to liver abscess in mice

BolA has been characterized as an important transcriptional regulator, which is induced in the stationary phase of growth and is often associated with bacterial virulence. This study was initiated to elucidate the role of the BolA in the virulence of K. pneumoniae. Using a mous...

2022-09-13 | MTBLS2712 | MetaboLights
TranscriptomicsA genome-wide transcriptome analysis reveals diverse roles of two-component system DraR-K in physiological and morphological differentiation of Streptomyces coelicolor
A novel two-component system (TCS) DraR-K was identified previously to play a differential role in antibiotic biosynthesis (ACT, RED and yCPK) of Streptomyces coelicolor M145 on defined minimal medium (MM) conditions. In order to assess whether DraR-K has more global roles, a genome-wide transcripto...
ORGANISM(S): Streptomyces coelicolor 
2014-03-10 | E-GEOD-55714 | biostudies-arrayexpress
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profile of yeast cells lacking the high affinity K+-transport system
Potassium is the major intracellular cation in S. cerevisiae, which can be concentrated up to 200-300 mM even from relatively low potassium (< 1 mM) environments. This is achieved by mean of a high affinity K+-transport system encoded by the genes TRK1 and TRK2. Recently, our group became interested...
ORGANISM(S): Saccharomyces cerevisiae 
2012-10-13 | E-GEOD-24711 | biostudies-arrayexpress
ProteomicsIdentification of vitamin K-dependent proteins in mouse liver by LC-MS/MS
Vitamin K (VK), a fat-soluble vitamin, functions as a co-factor during the gamma-carboxylation reaction that converts glutamic acid residues to gamma-carboxyglutamic acid residues in proteins transiting through the endoplasmic reticulum. Two enzymes are involved which together form the VK cycle: gam...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD032920 | Pride
Gamma-carboxylation Mouse Liver Vitamin k Lc-ms/ms 
TranscriptomicsTranscription profiling by array of Nipponbare rice roots over a time course of potassium deprivation
Potassium (K+) is one of the most important nutrient ions in plant cells and play crucial roles in many plant physiological and developmental processes. K+ deficiency is the common abiotic stress in natural environment, which inhibits plant growth and reduces production of crops. We used microarrays...
ORGANISM(S): Oryza sativa japonica 
2012-10-31 | E-GEOD-37161 | biostudies-arrayexpress
ProteomicsDesign principles for cyclin K molecular glue degraders
Molecular glue degraders are an effective therapeutic modality, but their design principles are not well understood. Recently, several unexpectedly diverse compounds were reported to deplete cyclin K by linking CDK12-cyclin K to the DDB1-CUL4-RBX1 E3 ligase. To investigate how chemically dissimilar ...
ORGANISM(S): Hordeum vulgare (Barley) 
2023-10-20 | PXD041836 | Pride
Ubiquitin Cdk12 Molecular glue Cr8 Cyclink Degrader 
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