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TranscriptomicsTranscription profiling of humans to investigate between transient vs acute megakaryoblastic leukaemia (TMD vs AMKL) in Downs syndrome
Comparison of transient myeloproliferative disorder and acute megakaryoblastic leukaemia in Down syndrome.
ORGANISM(S): Homo sapiens 
2004-09-01 | E-MEXP-72 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human Downs syndrome with acute lymphoblastic pediatric leukemia (DS-ALL) patients
DS-ALL is a highly heterogeneous disease with predominance of an aberrant exp. of CRLF2 cooperating with mutated JAK2; Acute lymphoblastic pediatric leukemia specimens of Down's syndrome are examined for gene expression profiles and specific genetic aberrations. Gene expression profiling and specifi...
ORGANISM(S): Homo sapiens 
2010-01-15 | E-GEOD-17459 | biostudies-arrayexpress
GenomicsDomains of genomewide gene expression dysregulation in Down syndrome [RRBS]
Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we sh...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-55505 | biostudies-arrayexpress
GenomicsDomains of genomewide gene expression dysregulation in Down syndrome [Dnase HS mapping]
Trisomy 21 (T21) is the most frequent genetic cause of cognitive impairment. To assess the perturbations of gene expression in T21, and to eliminate the noise of the genomic variability, we studied the transcriptome of fetal fibroblasts from a pair of monozygotic twins discordant for T21. Here we sh...
ORGANISM(S): Homo sapiens 
2014-04-08 | E-GEOD-55425 | biostudies-arrayexpress
UnknownDifferential effects of Down's syndrome and Alzheimer's neuropathology on default mode connectivity.
Not available
S-EPMC6865660 | biostudies-literature
TranscriptomicsDelayed cell cycling in DS Ts1Cje neural precursor cells results in gene expression dysregulation
Down syndrome neurophenotypes are characterized by mental retardation and a decreased brain volume. In order to identify whether deficits in proliferation, differentiation or survival could be responsible for this phenotype, neural precursor cells (NPCs) were isolated from the developing E14 neocort...
ORGANISM(S): Mus musculus 
2010-05-19 | E-GEOD-9805 | biostudies-arrayexpress
TranscriptomicsExpression data from Down syndrome and non-Down syndrome pediatric acute lymphoblastic leukemia cases
Gene expression profiling (GEP) can reveal characteristic signatures associated with distinct biologic subtypes of acute lymphoblastic leukemia (ALL). We performed GEP on Down syndrome (DS) and comparison non-Down syndrome (NDS) ALL cases to identify biologic differences between these groups. Ficoll...
ORGANISM(S): Homo sapiens 
2011-07-12 | E-GEOD-20910 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiles of brain samples from Down Syndrome subjects and controls.
Human DNA methylation Beadchip v1.2 was used to obtain DNA methylation profiles across approximately 486,000 CpGs. Dataset included 71 samples from multiple brain regions (cerebellum, temporal/occipital/frontal cortex). The goal was to evalute the effect of trisomy 21 on DNA methylation levels and e...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-63347 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse Ts1Cje (mouse model of Down syndrome) and euploids murine cerebellum during postnatal development
Transcriptome analysis of Ts1Cje (mouse model of Down syndrome) and euploids murine cerebellum during postnatal development Keywords = Down syndrome Keywords = Chromosome 21 Keywords = Transcriptome Keywords = Microarray Keywords = Cerebellum Keywords = Development Keywords: other
ORGANISM(S): Mus musculus 
2004-12-05 | E-GEOD-1611 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human adult postmortem brain tissue from Down syndrome and healthy control subjects
Down syndrome (DS) is the result of trisomy chromosome 21 but the mechanisms by which the genotype leads to the characteristic disease phenotype are unclear. We performed a microarray study using human adult brain tissue (dorsolateral prefrontal cortex) from DS subjects and healthy controls to chara...
ORGANISM(S): Homo sapiens 
2009-04-23 | E-GEOD-5390 | biostudies-arrayexpress
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