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UnknownThe DPY30-H3K4me3 Axis-Mediated PD-L1 Expression in Melanoma.
Not available
S-EPMC9525212 | biostudies-literature
TranscriptomicsThe DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells.
Epigenetic mechanisms including histone modifications have emerged as important factors influencing cell fate determination. The functional role of H3K4 methylation, however, remains largely unclear in the maintenance and differentiation of hematopoietic stem/progenitor cells (HSC/HPCs). Here we sho...
ORGANISM(S): Homo sapiens 
2014-09-01 | E-GEOD-59643 | biostudies-arrayexpress
ProteomicsJASPer controls interphase histone H3S10 phosphorylation by chromosomal kinase JIL-1 in Drosophila
In Drosophila the chromosomal kinase JIL-1 is responsible for most interphase histone H3S10 phosphorylation and has been proposed to protect active chromatin from acquiring heterochromatic marks, like dimethylated histone H3K9 (H3K9me2) and HP1. Here, we show that JIL-1’s targeting to chromatin depe...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2019-10-09 | PXD012790 | Pride
Jil-1 Pwwp Compass Chromatin B-jim Set1 H3s10ph Dpy30-l1 H3k36me3 Bod1 
Genomicsseq-SDQ3499_DPY30_N2_Mxemb
modENCODE_submission_6232 This submission comes from a modENCODE project of Jason Lieb. For full list of modENCODE projects, see http://www.genome.gov/26524648 Project Goal: The focus of our analysis will be elements that specify nucleosome positioning and occupancy, control domains of gene expressi...
ORGANISM(S): Caenorhabditis elegans 
2013-08-28 | E-GEOD-50307 | biostudies-arrayexpress
TranscriptomicsActivin regulates H3K4me3 in hPSC
Activin signalling controls the pluripotency of human embryonic stem cells (hESCs) by inducing the formation of nuclear Smad2/3-Nanog complexes that bind to and regulate several downstream targets. We aimed to clarify the transcriptional dynamics to the inhibition of Activin in hPSCs. To this end we...
ORGANISM(S): Homo sapiens 
2015-01-01 | E-MTAB-2749 | biostudies-arrayexpress
ProteomicsMultistate structures of the MLL1-WRAD complex bound to H2B-ubiquitinated nucleosome
The human Mixed Lineage Leukemia-1 (MLL1) complex orchestrates methylation of histone H3K4 to promote transcription and is the target of chromosomal translocations in a variety of leukemias. The MLL1 core complex comprises the MLL1 methyltransferase and the WRAD complex, which contains WDR5, RbBp5, ...
ORGANISM(S): Homo Sapiens (human) 
2023-08-31 | PXD036406 | JPOST Repository
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