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GenomicsContext Dependency of Set1/COMPASS Mediated H3 Lysine 4 Trimethylation
The stimulation of trimethylation of histone H3 lysine 4 (H3K4) by H2B monoubiquitination (H2Bub) has been widely studied with multiple mechanisms proposed for this form of histone crosstalk. Cps35/Swd2 within COMPASS is considered to bridge these processes. However, a truncated form of Set1 (762-Se...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-09 | E-GEOD-53241 | biostudies-arrayexpress
MetabolomicsLipid Data Analyzer: Decision rule set development by lipid standards of known constituent fatty acyl and/or alkyl/1-alkenyl chains and their respective sn-positions (Control experiment 1)

Lipid Data Analyzer (LDA; http://genome.tugraz.at/lda2) provides automated and reliable annotation of lipid species and their molecular structures in high-throughput data from chromatography-coupled tandem mass spectrometry using embedded rule sets. Using various low- and high-resolution mass spe...

2017-10-27 | MTBLS394 | MetaboLights
TranscriptomicsTranscriptome analysis of yeast methyltransferase mutants set5∆, set1∆ and set5∆set1∆
Purpose: Understand the synergistic relationship between the methyltransferases Set1 and Set5 in the regulation of gene expression. Methods: Total mRNA was obtained from two independent biological replicates each of wildtype (WT), set1∆, set5∆, SET5 Y402A and set1∆set5∆ S. cerevisiae strains. Libra...
ORGANISM(S): Saccharomyces cerevisiae 
2014-01-15 | E-GEOD-52086 | biostudies-arrayexpress
ProteomicsCla4 catalyzed Set1 phosphorylation
H3K4me3 is catalyzed by the Set1/MLL family of methyltransferases, whose function in catalyzing H3K4me3 is unique. Impaired function of Set1/MLL family members can lead to many abnormalities, such as bone and nerve defects, leukemia, and even death. Although the Set1 family plays an important regula...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-10-24 | PXD042010 | Pride
Cla4 set1 phosphorylation 
TranscriptomicsHistone H3 lysine9 acetylation, rather than lysine4 trimethylation, marks meiotic recombination hotspots and promotes recombination initiation in fission yeast
Histone modifications are associated with meiotic recombination hotspots, discrete sites with augmented recombination frequency. For example, trimethylation of histone H3 lysine4 (H3K4me3) marks most hotspots in budding yeast and mouse. Modified histones are known to regulate meiotic recombinatio...
ORGANISM(S): Schizosaccharomyces pombe 
2013-03-07 | E-GEOD-31648 | biostudies-arrayexpress
TranscriptomicsFeedback control of Set1 protein levels is important for proper H3K4 methylation patterns
Methylation of histone H3 lysine 4 by the Set1 subunit of COMPASS correlates withactive transcription. Here we show that Set1 levels are regulated by protein degradation in response to multiple signals. Set1 levels are greatly reduced when COMPASS recruitment to genes, H3K4 methylation, or transcrip...
ORGANISM(S): Saccharomyces cerevisiae 
2014-02-28 | E-GEOD-55082 | biostudies-arrayexpress
Transcriptomicsset1, H3K4A, set1htz1, set1htz1sir2 transcription profiles
Relative mRNA abundance of all S. cerevisiae genes was measured in various mutants, compared to wild-type mutant and wild-type grown to log phase, YPAD, 30C, purified mRNA, reverse-transcribed to cDNA, labelled with Cy5/Cy3, hybridized to whole genome ORF microarrays
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-11 | E-GEOD-4826 | biostudies-arrayexpress
ProteomicsQuantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes
Methylation of lysine 4 at histone H3 (H3K4) at promoters is tightly linked to transcriptional regulation in human cells. At least six different COMPASS-like multi-subunit (SET1/MLL) complexes have been described that contain methyltransferase activity towards H3K4, but a comprehensive and quantitat...
ORGANISM(S): Homo sapiens (Human) 
2013-09-13 | PXD000172 | Pride
Mll Set1 Ms Compass Histone methylation Human 
TranscriptomicsTranscriptional regulation by Set1 H3K4 methyltransferase and Jhd2 H3K4 demethylase
Histone H3K4 methylation is connected to gene transcription from yeast to humans, but its mechanistic role in transcription and chromatin dynamics remains poorly understood. Here, we investigated the functions for Set1 and Jhd2, the sole H3K4 methyltransferase and H3K4 demethylase, respectively, in ...
ORGANISM(S): Saccharomyces cerevisiae 
2016-06-15 | E-GEOD-73406 | biostudies-arrayexpress
ProteomicsIdentification of Set1 interacting protein in Fusarium graminearum
Affinity capture of H3K4me3 methyltransferase Set1
ORGANISM(S): Fusarium Graminearum Ph-1 
2024-12-24 | PXD059222 |
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