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ProteomicsDrug Affinity Responsive Target Stability unveils Filamins as biological targets for Artemetin, an anti-cancer flavonoid.
Artemetin is a valuable 5-hydroxy-3,6,7,3',4'-pentamethoxyflavone found in many different medicinal plants with a very good oral bioavailability and drug-likeness values endowed with numerous bioactivities such as anti-inflammatory and anti-cancer ones. Here, a multi-disciplinary strategy has been d...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034776 | Pride
Anti-cancer. Bioactive natural compounds Drug affinity responsive target stability Cytoskeleton Proteomics 
UnknownTarget identification using drug affinity responsive target stability (DARTS).
Not available
S-EPMC2789755 | biostudies-literature
UnknownDrug affinity-responsive target stability unveils filamins as biological targets for artemetin, an anti-cancer flavonoid.
Not available
S-EPMC9452882 | biostudies-literature
UnknownIdentification of Multiple Cryptococcal Fungicidal Drug Targets by Combined Gene Dosing and Drug Affinity Responsive Target Stability Screening.
Not available
S-EPMC4981720 | biostudies-literature
UnknownTarget identification of grape seed extract in colorectal cancer using drug affinity responsive target stability (DARTS) technique: role of endoplasmic reticulum stress response proteins.
Not available
S-EPMC4217504 | biostudies-literature
UnknownTarget engagement of ginsenosides in mild cognitive impairment using mass spectrometry-based drug affinity responsive target stability.
Not available
S-EPMC9597435 | biostudies-literature
ProteomicsAzeliragon in Drug Affinity Responsive Target Stability (DARTS) Assay
Using Darts to identify the drug target of Azeliragon for the treatment of Staphylococcus aureus
ORGANISM(S): Staphylococcus Aureus 
2026-01-22 | PXD073387 |
ProteomicsIdentifying target proteins of capsazepine using DARTS technology
This study employs DARTS (Drug Affinity Responsive Target Stability) to investigate capsazepine's targets. The technique detects drug-induced proteolytic resistance in target proteins, coupled with mass spectrometry to capture drug-protein complexes. Experiments focus on identifying novel targets be...
ORGANISM(S): Mus Musculus 
2025-02-23 | PXD061112 |
ProteomicsTarget of L-menthol in keratinocytes
To elucidate the PP6-upregulation mechanism of L-menthol, we took advantage of an unbiased target identification approach, DARTS, to identify the target of L-menthol in keratinocytes.
ORGANISM(S): Homo sapiens (Human) 
2022-11-09 | PXD037335 | Pride
Keratinocyte，hes1 L-menthol 
ProteomicsRepurposing Lusutrombopag: Unveiling Anti-Staphylococcus aureus Activity in a Novel Oral Thrombopoietin Receptor Agonist
Here are the findings from the DARTs (Drug Affinity Responsive Target Stability) and proteomics studies for Lusutrombopag
ORGANISM(S): Staphylococcus Aureus Subsp. Aureus Nctc 8325 
2025-12-17 | PXD072172 |
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