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ProteomicsPhosphoproteomics landscape of lung DTP
Osimertinib is the first-line therapy for EGFR-mutated non-small cell lung cancer, but acquired resistance commonly develops, linked to a drug-tolerant persister (DTP) cell state that promotes survival and eventual resistance. Using data-independent acquisition mass spectrometry (DIA-MS), we mapped ...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD058009 | Pride
Lc-msms Lung Huamn Dtp 
GenomicsThe Ontogeny and Vulnerabilities of Lapatinib Drug Tolerant Persisters [Parental (P) vs. Drug-Tolerant Persister (DTP)]
The Ontogeny and Vulnerabilities of Lapatinib Drug Tolerant Persisters [Parental (P) vs. Drug-Tolerant Persister (DTP)]
PRJNA649434 | ENA
ProteomicsThe Yin and Yang of GDF15: a secreted biomarker of eribulin response in breast cancer cells, yet required for survival of drug tolerant persister (DTP) cells
Drug tolerant persister (DTP) cells enter into a reversible slow-cycling state after cancer drug treatment. These cells are the living proof of response to a drug, and an interesting experimental subject for biomarker discovery. Here, we performed proteomic characterization of the breast cancer (BC)...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD034037 | Pride
Eribulin Drug tolerance Growth differentiation factor (gdf15) Secretome. Drug tolerant persister (dtp) Breast cancer (bc) 
GenomicsChromasome accessibility profiles at single cell level of Drug-tolerant persister cells induced by targeted therapy in lung adenocarcinoma.
Drug-tolerant persister (DTP) stage is viewed as a major source of non-genetic drug resistance. We use single cell ATAC seq to reveal the epigenetic heterogeniety of DTP stage
ORGANISM(S): Homo sapiens 
2025-05-14 | GSE275305 | GEO
TranscriptomicsGene expression profile at single cell level of Drug-tolerant persister cells induced by targeted therapy in lung adenocarcinoma.
Drug-tolerant persister (DTP) stage is viewed as a major source of non-genetic drug resistance. We use single cell RNA seq to reveal the transcriptomic heterogeniety of DTP stage
ORGANISM(S): Homo sapiens 
2025-05-14 | GSE275199 | GEO
GenomicsHistone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma [RKI1_DTPs_RNAseq]
Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma [RKI1_DTPs_RNAseq]
PRJNA1122510 | ENA
GenomicsDasatinib suppresses apatinib-induced drug-tolerant persister cells proliferation by acting on SRC in gastric cancer
Dasatinib suppresses apatinib-induced drug-tolerant persister cells proliferation by acting on SRC in gastric cancer
PRJNA1522826 | ENA
TranscriptomicsDasatinib suppresses apatinib-induced drug-tolerant persister cells proliferation by acting on SRC in gastric cancer
Drug-tolerant persister (DTP) cells play a significant role in therapeutic resistance and tumor recurrence. In this study, RNA sequencing was conducted to characterize the transcriptomic alterations associated with the formation of DTP cells induced by apatinib in gastric cancer cells. The gene expr...
ORGANISM(S): Homo sapiens 
2026-09-08 | GSE346057 | GEO
UnknownATF3 characterizes aggressive drug-tolerant persister cells in HGSOC.
Not available
S-EPMC11043376 | biostudies-literature
GenomicsHistone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma [RNA-seq]
Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma [RNA-seq]
PRJNA1090907 | ENA
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