Sort   by:  
 Page size 
TranscriptomicsExpression data for human retinal pigment epithelium (RPE)/choroid - early age-related macular degeneration (AMD) and control samples
Purpose: Age-related degeneration (AMD) is a major cause of blindness in developed countries. The molecular pathogenesis of early events in AMD is poorly understood. We investigated differential gene expression in samples of human retinal pigment epithelium (RPE)/choroid from early AMD and control m...
ORGANISM(S): Homo sapiens 
2013-12-23 | E-GEOD-50195 | biostudies-arrayexpress
TranscriptomicsDry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. There are two types of AMD: dry AMD and wet AMD. While laser-induced choroidal neovascularization has been used extensively in the studies of wet AMD by presenting the main features of human wet AMD, there was no ...
ORGANISM(S): Mus musculus 
2016-08-10 | E-GEOD-85408 | biostudies-arrayexpress
ProteomicsThe Proteomic Landscape in the Vitreous of Patients With Age-Related and Diabetic Retinal Disease
In contrast to neovascular age-related macular degeneration (nAMD), no treatment option exists for dry AMD. The identification of specific biomarkers is required to facilitate diagnosis and therapy of dry AMD. We thus measured the proteome of 34 vitreous humor samples (dry AMD: n = 6, nAMD: n = 10, ...
ORGANISM(S): Homo sapiens (Human) 
2018-07-23 | PXD008354 | Pride
Pdr Proliferative diabetic retinopathy Dry amd Age-related macular degeneration Neovascular amd Epiretinal membrane Vitreous proteome Human Biomarker Vitreous humor Namd Erm 
TranscriptomicsMicroglia-RPE Cell Communication via the SPP1-ITGAV Axis Drives EMT and Retinal Degeneration in Dry AMD
Age-related macular degeneration (AMD) is a leading cause of vision loss, with its dry form characterized by retinal pigment epithelium (RPE) degeneration and photoreceptor loss. However, the underlying mechanisms driving these pathological changes remain poorly understood. Here, we identify a criti...
ORGANISM(S): Homo sapiens 
2024-11-12 | GSE281280 | GEO
GenomicsMicroglia-RPE Cell Communication via the SPP1-ITGAV Axis Drives EMT and Retinal Degeneration in Dry AMD
Microglia-RPE Cell Communication via the SPP1-ITGAV Axis Drives EMT and Retinal Degeneration in Dry AMD
PRJNA1183307 | ENA
UnknownIntegrative Landscape of Dry AMD Pathogenesis, Models, and Emerging Therapeutic Strategies.
Not available
S-EPMC12786248 | biostudies-literature
TranscriptomicsDry age-related macular degeneration like pathology in aged 5XFAD mice: Ultrastructure and microarray analysis
Age-related macular degeneration (AMD) is a leading cause of blindness in the elderly. There are two types of AMD: dry AMD and wet AMD. While laser-induced choroidal neovascularization has been used extensively in the studies of wet AMD by presenting the main features of human wet AMD, there was no ...
ORGANISM(S): Mus musculus 
2016-08-10 | GSE85408 | GEO
UnknownRPE-Directed Gene Therapy Improves Mitochondrial Function in Murine Dry AMD Models.
Not available
S-EPMC9968062 | biostudies-literature
UnknownThe role of IGF2BP2 in macrophage-mediated NLRP3 inflammasome activation in the pathogenesis of dry AMD.
Not available
S-EPMC12016075 | biostudies-literature
UnknownThree-Dimensional Choroidal Vessel Analysis in Asymmetric Bilateral Age-Related Macular Degeneration: A Comparison of Active Neovascular AMD and Dry AMD Fellow Eyes.
Not available
S-EPMC12312765 | biostudies-literature
Sort   by:  
 Page size