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TranscriptomicsDsbA plays a critical and multi-faceted role in the production of secreted virulence factors by Erwinia carotovora
Erwinia carotovora subsp. atroseptica (Eca) is an enterobacterial phytopathogen causing economically-significant soft rot disease. Pathogenesis is mediated by multiple secreted virulence factors, many of which are secreted by the Type II (Out) secretion system. DsbA catalyses the introduction of dis...
ORGANISM(S): Pectobacterium carotovorum 
2010-06-20 | E-GEOD-10647 | biostudies-arrayexpress
ProteomicsThe periplasmic oxidoreductase DsbA is required for virulence of the phytopathogen Dickeya solani
The DsbA oxidoreductase is a crucial factor responsible for introduction of disulfide bonds to the extracytoplasmic proteins in bacteria. A lack of the proper disulfides frequently leads to instability and/or loss of protein function. In pathogens, numerous envelope and extracellular proteins play i...
ORGANISM(S): Dickeya solani 
2022-02-15 | PXD028047 | Pride
Dickeya solani Swath-ms Dsba Lc-ms/ms 
ProteomicsFrancisella tularensis DsbA mutant MS/SILAC analysis
Comparison of enriched membrane fractions of Francisella tularensis subsp. holarctica strain FSC200 and its DsbA mutant by SILAC analysis.
ORGANISM(S): Francisella tularensis subsp. holarctica FSC200 
2018-01-15 | PXD007682 | Pride
Q-exactive Silac Francisella tularensis 
UnknownInhibition of Diverse DsbA Enzymes in Multi-DsbA Encoding Pathogens.
Not available
S-EPMC6067686 | biostudies-literature
GenomicsThe SIRT3-DsbA-L-TFAM Axis Suppresses Liver cGAS Signaling and MASH Progression in Male Mice
The SIRT3-DsbA-L-TFAM Axis Suppresses Liver cGAS Signaling and MASH Progression in Male Mice
PRJNA1185201 | ENA
TranscriptomicsDsbA plays a critical and multi-faceted role in the production of secreted virulence factors by Erwinia carotovora
Erwinia carotovora subsp. atroseptica (Eca) is an enterobacterial phytopathogen causing economically-significant soft rot disease. Pathogenesis is mediated by multiple secreted virulence factors, many of which are secreted by the Type II (Out) secretion system. DsbA catalyses the introduction of dis...
ORGANISM(S): Pectobacterium carotovorum Pectobacterium atrosepticum 
2008-08-26 | GSE10647 | GEO
TranscriptomicsThe SIRT3-DsbA-L-TFAM Axis Suppresses Liver cGAS Signaling and MASH Progression in Male Mice
While mitochondrial dysfunction is implicated in metabolic dysfunction associated steatohepatitis (MASH), the precise underlying mechanisms remain obscure. Here, we identify the SIRT3-DsbA-L-TFAM axis as a crucial suppressor for mitochondrial stress-induced cGAS activation in the hepatocytes, thereb...
ORGANISM(S): Mus musculus 
2024-11-30 | GSE281667 | GEO
GenomicsDsbA-L deficiency attenuates LPS-induced acute kidney injury via NF-κB/AP-1 regulation of macrophage polarization
DsbA-L deficiency attenuates LPS-induced acute kidney injury via NF-κB/AP-1 regulation of macrophage polarization
PRJNA837207 | ENA
TranscriptomicsDsbA-L deficiency attenuates LPS-induced acute kidney injury via NF-κB/AP-1 regulation of macrophage polarization
Background: Disulfide bond A oxidoreductase-like protein (DsbA-L) drives acute kidney injury (AKI) progression in proximal tubular cells by directly upregulating voltage-dependent anion-selective channel levels; however, its role in immune cells remains unclear. Methods: We used the mouse model of A...
ORGANISM(S): Mus musculus 
2025-05-10 | GSE202753 | GEO
UnknownDsbA is a redox-switchable mechanical chaperone.
Not available
S-EPMC8386657 | biostudies-literature
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