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ProteomicsRapid and direct control of target protein levels with VHL-recruiting dTAG molecules
Chemical biology strategies for directly perturbing protein homeostasis including the degradation tag (dTAG) system provide temporal advantages over genetic approaches and improved selectivity over small molecule inhibitors. We describe dTAGV-1, an exclusively selective VHL-recruiting dTAG molecule,...
ORGANISM(S): Homo sapiens (Human) 
2020-09-21 | PXD018937 | Pride
Proteomics Protac Dtag Degraders 
UnknownThe dTAG system for immediate and target-specific protein degradation.
Not available
S-EPMC6295913 | biostudies-literature
UnknownUse of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities.
Not available
S-EPMC10306401 | biostudies-literature
TranscriptomicsATAC-seq data of mouse embryonic stem cells treated with dTAG for SALL4 depletion against untreated control
This study investigates the role of SALL4 in regulating chromatin accessibility. SALL4 was tagged with FKBP to enable dTAG-inducible degradation. ATAC-seq was performed at multiple time-points (1 hour, 4 hours and 8 hours) following dTAG treatment to capture changes in chromatin accessibility upon S...
ORGANISM(S): Mus musculus 
2026-01-15 | E-MTAB-15375 | biostudies-arrayexpress
GenomicsRapid and efficient adaptation of the dTAG system in mammalian development reveals stage specific requirements of NELF
Rapid and efficient adaptation of the dTAG system in mammalian development reveals stage specific requirements of NELF
PRJNA767647 | ENA
UnknownRapid and direct control of target protein levels with VHL-recruiting dTAG molecules.
Not available
S-EPMC7501296 | biostudies-literature
GenomicsUse of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities [Duodenum]
Use of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities [Duodenum]
PRJNA940124 | ENA
TranscriptomicsUse of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities [Duodenum]
The degradation tag (dTAG) system for target protein degradation can remove proteins from biological systems without the drawbacks of some genetic methods, such as slow kinetics, lack of reversibility, low specificity, and the inability to titrate dosage. These drawbacks can make it difficult to com...
ORGANISM(S): Mus musculus 
2023-05-28 | GSE226388 | GEO
TranscriptomicsThe dTAG system for immediate and target-specific protein degradation
The dissection of complex biological systems requires target-specific control of protein function or abundance. Genetic perturbations have markedly advanced science but are variably limited by off-target effects, multi-component complexity and irreversibility. Most limiting to the study of fast biol...
ORGANISM(S): Mus musculus 
2018-04-25 | GSE92775 | GEO
TranscriptomicsUse of the dTAG system in vivo to degrade CDK2 and CDK5 in adult mice and explore potential safety liabilities [Bone marrow]
The degradation tag (dTAG) system for target protein degradation can remove proteins from biological systems without the drawbacks of some genetic methods, such as slow kinetics, lack of reversibility, low specificity, and the inability to titrate dosage. These drawbacks can make it difficult to com...
ORGANISM(S): Mus musculus 
2023-05-28 | GSE226386 | GEO
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