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ProteomicsLung proteome of the AAV-DTR/DT mouse model of acute epithelial lung injury
Injury of the lung epithelium is one of the initial events driving acute lung diseases such as acute lung injury and acute respiratory distress syndrome. Repeated epithelial injury followed by aberrant repair leads to fibroblast activation and extracellular matrix deposition and is therefore conside...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2021-12-04 | MSV000088510 | MassIVE
GenomicsScRNA-seq of stromal cells in WT and LRRC15 DTR mice
ScRNA-seq of stromal cells in WT and LRRC15 DTR mice
PRJEB55257 | ENA
TranscriptomicsGene expression profiling of NK cells isolated from the pancreas of BDC TCR expressing NOD mice before or after Treg ablation by DTR. Also, NK cells cultured in vitro with activating cytokines IL12 and IL-18 with or without regulatory TGFb.
Following Treg ablation in the BDC/NOD.Foxp3-DTR strain, NK cells produce IFNg and accumulate to higher percentage and number. We explored the signature pathways responsible for this phenomenon using microarray prolifing and comparison to other activation signatures. All microarray populations were...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-39197 | biostudies-arrayexpress
ProteomicsSpatial resolution of proteomic changes in lung tissue from a flexible AAV-DTR/DT mouse model of acute cell deletion mimicking epithelial lung injury
Lung epithelial injury leads to different pathologies, all associated with severe outcome and increased mortality. These pathologies are divided into chronic and acute diseases like idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD) or the acute lung distress syndrome ...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-30 | PXD025712 | Pride
Laser-capture microdissection Tmt Diphtheria toxin Ffpe Aav Dtr Epithelial cells 
TranscriptomicsScRNA-seq of stromal cells in WT and LRRC15 DTR mice
KPR tumors were subcutaneously implanted in Lrrc15DTRGFPwt/wt (DTR–) or Lrrc15DTRGFPwt/ki (DTR+) mice and DT treatment was initiated in both DTR– and DTR+ mice when tumors reached a mean volume of 100-200mm3. scRNAseq of CD24-CD45- stromal cells from a total of 40 tumor-bearing animals across both D...
ORGANISM(S): Mus musculus 
2022-08-17 | E-MTAB-12036 | biostudies-arrayexpress
GenomicsExpression profiles of satellite cells and alpha7Sca1 cells in mdxITGAM-DTR mice
Expression profiles of satellite cells and alpha7Sca1 cells in mdxITGAM-DTR mice
PRJNA556367 | ENA
TranscriptomicsTranscriptional profiling of senescent cell-associated genes in adult mouse lung.
To evaluate the senescent cell-dependent gene expression in aged lung tissue, young (2mo) ARF-DTR mice and adult (12mo) ARF-DTR mice treated with PBS or DT every two weeks up to 1 month were analyzed using the Agilent Technologies SurePrint G3 Mouse Gene Expression Microarray. Gene expression in lun...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-64754 | biostudies-arrayexpress
ProteomicsChronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertility disorders
We characterized the sperm proteins recognized by the antibodies in mouse serum and epididymal fluid after immune tolerance disruption by performing mass spectrometry-based label-free quantitative proteomics. For this, we immunoprecipitated sperm cell protein extractions with serum and epididymal fl...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-10 | PXD062944 | Pride
Autoanti-sperm antibodies Serum Treg depletion Immune tolerance Epididymal fluid 
ProteomicsChronic inflammation drives epididymal tertiary lymphoid structure formation and autoimmune fertility disorders
We characterized the sperm proteins recognized by the antibodies in mouse serum and epididymal fluid after immune tolerance disruption by performing mass spectrometry-based label-free quantitative proteomics. For this, we immunoprecipitated sperm cell protein extractions with serum and epididymal fl...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-10 | PXD058247 | Pride
Autoanti-sperm antibodies Serum Treg depletion Immune tolerance Epididymal fluid 
TranscriptomicsExpression data from FITC challenged skin of CLEC4C-DTR mice vs. littermate controls treated with diptheria toxin
CLEC4C-DTR exhibit exacerbated contact hypersensitivty to the FITC hapten. Here we assess the transcriptional differences in whole skin of FITC challenged CLEC4C-DTR+ mice and DTR- mice treated with diptheria toxin. Overall, CLEC4C-DTR upregualated 439 genes and downregulated 152 genes compared to t...
ORGANISM(S): Mus musculus 
2020-10-28 | GSE160261 | GEO
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