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ProteomicsShigella hijacks the exocyst to cluster macropinosomes for efficient vacuolar escape
Shigella flexneri invades host cells by entering within a bacteria-containing vacuole (BCV). In order to establish its niche in the host cytosol, the bacterium ruptures its BCV. Contacts between S. flexneri BCV and infection-associated macropinosomes (IAMs) formed in situ have been reported to enhan...
ORGANISM(S): Shigella flexneri 5a str. M90T 
2021-08-11 | PXD020161 | Pride
Macropinosomes Shigella 
ProteomicsOptimization of a Top-Down Proteomics Platform for Closely-Related Pathogenic Bacteria Discrimination
The current technique used for microbial identification in hospitals is MALDI-TOF MS. However, it suffers from important limitations, in particular for closely-related species or when the database used for the identification lacks the appropriate reference. In this work, we set up a high throughput ...
ORGANISM(S): Shigella flexneri Salmonella enterica subsp. enterica serovar Muenchen Salmonella enterica subsp. enterica serovar Enteritidis Salmonella enterica subsp. enterica serovar Typhimurium Escherichia coli O26:H11 Shigella sonnei Escherichia coli O157:H7 Salmonella enterica subsp. enterica serovar Newport Escherichia coli 
2020-09-24 | PXD019247 | Pride
Mass spectrometry Optimization Top-down proteomics Bacteria 
ProteomicsNAD kinase promotes Staphylococcus aureus pathogenesis by supporting production of virulence factors and protective enzymes
Nicotinamide adenine dinucleotide phosphate (NADPH) is the primary electron donor for reductive reactions that are essential for the biosynthesis of major cell components in all organisms. Nicotinamide adenine dinucleotide kinase (NADK) is the only enzyme that catalyzes synthesis of NADP(H) from NAD...
ORGANISM(S): Staphylococcus aureus 
2022-08-12 | PXD032968 | Pride
Staphylococcus aureus Nicotinamide adenine dinucleotide kinase 
ProteomicsOuter Membrane Proteome of Veillonella parvula: a Diderm Firmicute of the Human Microbiome
Veillonella parvula is a biofilm-forming commensal found in the lungs, vagina, mouth, and gastro-intestinal tract of humans, yet it may also develop into an opportunistic pathogen. Furthermore the presence of Veillonella has been associated with the development of a healthy immune system in infants....
ORGANISM(S): Veillonella parvula DSM 2008 
2017-07-19 | PXD005929 | Pride
Outer membrane proteome Veillonella parvula 
ProteomicsThe puzzling construction of the conidial outer layer of Aspergillus fumigatus
The outer layers of the fungal cell wall are the first barrier facing external challenges. In theinvasive morphotype of the airborne pathogen Aspergillus fumigatus, i.e. conidia, the outer cell wall consists of α-(1,3)-glucan, melanin and proteinaceous rodlets made up by the RodA hydrophobin. The h...
ORGANISM(S): Aspergillus fumigatus CEA10 
2019-01-30 | PXD011734 | Pride
Conida Aspergillus fumigatus Out layer 
ProteomicsProteomic analysis of humoral immune components in bronchoalveolar lavage of patients infected or colonized by Aspergillus fumigatus
Humoral immune factors have been individually studied in the context of host-Aspergillus fumigatus interaction. However, a global view of the multitude and complex nature of humoral factors is needed to bring new insight into the pathobiology of aspergillosis. Therefore, we undertook proteomic analy...
ORGANISM(S): Homo sapiens (Human) Aspergillus fumigatus Af293 
2021-08-11 | PXD023417 | Pride
Alveolar humoral factors Bronchoalveolar lavage Aspergillus fumigatus 
ProteomicsH. pylori utilizes membrane vesicles as a novel tool to extrude bismuth drug
Antibiotic resistance is one of the major threats to human health. Combination of antibiotics with metals is among the proposed alternative treatments. However, so far only one such combination with the metal bismuth successfully used in clinics against Helicobacter pylori. This bacterial pathogen c...
ORGANISM(S): Helicobacter pylori G27 
2022-09-19 | PXD028509 | Pride
Bismuth Helicobater pylori Antibiotic resistance Membrane vesicle 
ProteomicsA time-resolved multi-omics atlas of Acanthamoeba castellanii encystment
Encystment is a common response of most protists to stress. Although some signaling pathways regulating this process were reported, our knowledge remains limited. Here, we mapped the molecular changes occurring in the amoeba Acanthamoeba castellanii during the early steps of encystment. De novo anal...
ORGANISM(S): Acanthamoeba castellanii str. Neff 
2022-07-12 | PXD031788 | Pride
Acanthamoeba castellanii Encystment Time-resolved molecular atlas 
ProteomicsInfection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis
Transglutaminase 2 (TG2) is a ubiquitous enzyme with transamidating activity. We report here that the expression and activity of TG2 are enhanced in cells infected with the obligate intracellular bacteria Chlamydia trachomatis. Genetic or pharmacological inhibition of TG2 activity impair bacterial d...
ORGANISM(S): Homo sapiens (Human) Chlamydia trachomatis E/C599 
2020-02-25 | PXD017117 | Pride
Chlamydia Hexosamine biosynthesis O-glcnacylation Gfpt Transglutaminase 2 
ProteomicsSalmonella mediated intracellular niche control by SCV size regulation
Salmonella is a human and animal pathogen causing gastro-enteric diseases worldwide. The key feature of Salmonella infection is its entry into intestinal epithelial cells within a Salmonella-Containing Vacuole (SCV). This original compartment is distinct from empty macropinosomes formed around the...
ORGANISM(S): Salmonella enterica subsp. enterica serovar Typhimurium 
2020-01-09 | PXD012825 | Pride
Membrane trafficking Membrane rupture Magnetic extraction Tubule formation Macropinosome Membrane fusion Salmonella containing vacuole Snare Salmonella enterica serovar typhimurium Svat 
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