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TranscriptomicsPediatric rhabdoid tumors of kidney and brain show many differences in gene expression but share dysregulation of cell cycle and epigenetic effector genes
Rhabdoid tumors (RTs) are aggressive tumors of early childhood that occur most often in brain (AT/RTs) or kidney (KRTs). Regardless of location, they are characterized by loss of functional SMARCB1 protein, a component of the SWI/SNF chromatin remodeling complex. The aim of this study was to determi...
ORGANISM(S): Homo sapiens 
2013-01-21 | E-GEOD-35493 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of human cells for whole genome profiling of 4 histone modifications
Whole genome profiling of 4 histone modifications (H3K27me1, H3K27me3,H3K36me1 and H3K36me3) using ChIP-on-chip. It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons ("exon-intron marking"), l...
ORGANISM(S): Homo sapiens 
2010-12-03 | E-MTAB-336 | biostudies-arrayexpress
TranscriptomicsChIP-chip by array of human K562, U937 and CD14+ cells to identify histone modifcations in ENCODE regions
Chromatin immunoprecipitation microarray (ChIP-chip) study using 3 human cell lines (K562, U937, CD14+); of 19 histone modifications across 1% of the human genome used in the pilot phase of the ENCODE project.
paper abstract: It has recently been shown that nucleosome distribution, histone modifi...
ORGANISM(S): Homo sapiens 
2010-12-29 | E-MTAB-334 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human cancer cell lines K562 and U937
Transcription profiling of two cancer cell lines: K562 and U937. It has recently been shown that nucleosome distribution, histone modifications and RNA polymerase II (Pol II) occupancy show preferential association with exons ("exon-intron marking"), linking chromatin structure and function to co- t...
ORGANISM(S): Homo sapiens 
2010-12-03 | E-MTAB-335 | biostudies-arrayexpress
TranscriptomicsHigh expression of BMP pathway genes distinguishes a subset of Atypical Teratoid/Rhabdoid Tumors associated with shorter survival
Molecular profiling of tumors has proven a valuable tool for identification of prognostic and diagnostic subgroups in medulloblastomas, glioblastomas and other cancers. However, the molecular landscape of atypical teratoid / rhabdoid tumors (AT/RTs) remains largely unexplored. To address this issue,...
ORGANISM(S): Homo sapiens 
2011-09-21 | E-GEOD-28026 | biostudies-arrayexpress
Genomicsena-DATASET-BTRC-03-04-2014-18:00:02:250-43 - samples
Whole genome alignments of DIPG patients
EGAD00001000814 | EGA
TranscriptomicsAffymetrix SNP 6.0 array data for Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and choosing therapies based on assumptions that DIPGs...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-50024 | biostudies-arrayexpress
TranscriptomicsIllumina Infinium 450K array data for Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and choosing therapies based on assumptions that DIPGs...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-50022 | biostudies-arrayexpress
TranscriptomicsIllumina HT-12 expression array data for Diffuse Intrinsic Pontine Glioma
Diffuse Intrinsic Pontine Glioma (DIPG) is a fatal brain cancer that arises in the brainstem of children with no effective treatment and near 100% fatality. The failure of most therapies can be attributed to the delicate location of these tumors and choosing therapies based on assumptions that DIPGs...
ORGANISM(S): Homo sapiens 
2014-03-31 | E-GEOD-50021 | biostudies-arrayexpress
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