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ProteomicsDynamic phosphoproteomics yeast rapamycin-induced shift
To resolve the temporal sequence of phosphorylation events responding to nutritional and chemically induced up and downshifts of TORC1 signaling in S. cerevisiae wildtype, we performed quantitative MS phosphoproteomics upon nitrogen-quality up and downshifts and rapamycin treatment. We generated a h...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-22 | PXD000940 | Pride
Yeast Dynamic phosphoproteomics Saccharomyces cerevisiae Rapamycin Glutamine Nitrogen shift 
UnknownPositive-unlabeled ensemble learning for kinase substrate prediction from dynamic phosphoproteomics data.
Not available
S-EPMC4739180 | biostudies-literature
UnknownDynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs.
Not available
S-EPMC6398214 | biostudies-literature
ProteomicsDynamic phosphoproteomics of BRS3 activation reveals Hippo signaling pathway for cell migration
Bombesin receptor subtype-3 (BRS3) is an orphan G-protein coupled receptor (GPCR) that involved in a range of pathological and physiological processes, while its biological functions and underlying regulatory mechanisms remain largely unknown. Quantitative phosphoproteomics approach was employed in ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-12 | PXD035666 | Pride
Phosphoproteomics Hippo signaling pathway Signaling transductions Gpcr Cell migration 
ProteomicsDynamic phosphoprotemics yeast nitrogen down-shift
To resolve the temporal sequence of phosphorylation events responding to nutritional and chemically induced up and downshifts of TORC1 signaling in S. cerevisiae wildtype, we performed quantitative MS phosphoproteomics upon nitrogen-quality up and downshifts and rapamycin treatment. We generated a h...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-22 | PXD000939 | Pride
Yeast Dynamic phosphoproteomics Proline Saccharomyces cerevisiae Glutamine Nitrogen shift 
ProteomicsPhosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes
Acute myeloid leukemia (AML) is a disease with poor outcome but patients harbouring certain chromosomal rearrangements or complex karyotypes have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular landsc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD032980 | Pride
Aml Phosphoproteomics Genomics Kmt2a Impdh Drug screen Nucleolus Proteomics 
ProteomicsPhosphoproteomics identifies determinants of PAK inhibitor sensitivity in AML cells
Background The p21 activated kinases (PAK) are frequently dysregulated in cancer and have central roles in oncogenic signalling, prompting the development of PAK inhibitors (PAKi) as anticancer agents. However, such compounds have not reached clinical use because, at least partially, there is a lim...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD056514 | Pride
Acute myeloid leukaemia Phosphoproteomics Machine learning Kinase inhibitors Pak inhibitors Target therapy Pf-3758309 Proteomics Biomarkers Cancer 
ProteomicsIn vivo Brain GPCR Signaling Elucidated by Phosphoproteomics
Obtaining a systems view of G protein-coupled receptor (GPCR) signaling in its native environment is the key in development of GPCR therapeutics with fewer side effects. Using the kappa opioid receptor (KOR) as model GPCR, we employed high-throughput phosphoproteomics to investigate downstream signa...
ORGANISM(S): Mus musculus (Mouse) 
2018-06-15 | PXD006637 | Pride
Gpcr brain phosphoproteomics 
ProteomicsDynamic phosphoprotemics yeast nitrogen up-shift
To resolve the temporal sequence of phosphorylation events responding to nutritional and chemically induced up and downshifts of TORC1 signaling in S. cerevisiae wildtype, we performed quantitative MS phosphoproteomics upon nitrogen-quality up and downshifts and rapamycin treatment. We generated a h...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-02-22 | PXD000911 | Pride
Proline Dynamic phosphoproteomic Glutamine Yeast Nitrogen upshift 
ProteomicsInstaNovo-P T47D cell phosphoproteomics
Phosphorylation, a vital post-translational modification (PTM), plays a central role in cellular signaling and disease mechanisms. Mass spectrometry-based phosphoproteomics is widely used for system-wide characterization of phosphorylation events. However, traditional methods struggle with accurate ...
ORGANISM(S): Homo sapiens (Human) 
2026-03-17 | PXD062859 | Pride
Breast cancer Growth factor Phosphoproteomics 
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