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MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
ProteomicsProteomic quantification of native and ECM-enriched mouse ovaries reveals an age-dependent fibro-inflammatory signature
The ovarian microenvironment becomes fibrotic and stiff with age due in part to increased stromal collagen and decreased hyaluronan. However, the extracellular matrix (ECM) is a complex network of hundreds of proteins, glycoproteins and glycans which are highly tissue specific and undergo pronounced...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-04-24 | MSV000091790 | MassIVE
ProteomicsGlobal proteomic analysis of extracellular matrix in mouse and human brain highlights association with cerebrovascular disease
The extracellular matrix (ECM), a key interface between the cerebrovasculature and other cells within the neuro-glial-vascular unit , provides structural stability and modulates cell behaviour and signalling. These functions are dependent on ECM protein composition. Since ECM defects may contribute ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2021-03-11 | PXD020436 | Pride
Ecm Basement membrane Cerebrovascular Matrisome Proteome Extracellular matrix 
ProteomicsComparative Wnt dependent Hydra ECM proteome
Comparative proteome of extracted Hydra vulgaris AEP extracellular matrix form Wnt9/10 knock out and Azakenpaullone treated animals. Used to analyse the changes in molecular composition of the mesoglea (ECM) of normal and Wnt depleted animals
ORGANISM(S): Hydra vulgaris 
2023-05-10 | PXD039846 | Pride
Mesoglea Wnt Extracellular matrix Hydra 
ProteomicsECM of proliferative vs dormant HNSCC
The goal of this project is to characterize the ECM composition of actively proliferative and dormant head and neck squamous cell carcinoma xenografts and identify components of the ECM niche instructing tumor cell dormancy.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-09-06 | PXD036453 | Pride
Tumor dormacy Xenografts Head and neck squamous cell carcinoma Extracellular matrix Tumor microenvironment 
ProteomicsAnalysis of ECM-enriched samples using different methods
Using LC-MS/MS, we analyzed ECM-enriched samples obtained from 1) human triple-negative breast cancer samples and matched adjacent normal mammary gland tissues, and 2) disease-free omentum from patient with non-metastatic ovarian cancer and high-grade- serous-ovarian- cancer-derived omental metastas...
ORGANISM(S): Homo sapiens (Human) 
2017-07-11 | PXD005554 | Pride
Breast cancer Ovarian cancer Ecm Lc-ms/ms 
ProteomicsFOXL1+ TELOCYTES IN MOUSE COLON ORCHESTRATE ECM BIODYNAMICS AND WOUND REPAIR RESOLUTION
Recent studies identified FoxL1+-Telocytes (TCFoxL1+) as key players in gut epithelial-mesenchymal interactions impacting the microenvironment. Disruption of BMP-signaling in TCFoxL1+ alters the physical and cellular microenvironment leading to gut pathophysiology, suggesting a role for TCFoxL1+ in ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-11 | PXD036294 | Pride
Bmp signaling  extracellular matrix  mechanical microenvironment  matrisome Foxl1+-telocytes  epithelial-mesenchymal communication 
ProteomicsExtracellular matrix proteome remodeling with substrate stiffness
Extracellular matrix proteomic profiling Mass spectrometry characterization illustrated a reprogrammed proteome in response to matrix stiffness, including a core subset of 84 ECM-specific proteins, including various ECM regulators and tissue-associated ECM-related proteins. Further, we observe remod...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000092971 | MassIVE
ProteomicsECM-Focused Proteomic Analysis of Ear Punch Regeneration in Acomys cahirinus
In mammals, significant injury is generally followed by the formation of a fibrotic scar which provides structural integrity but fails to functionally restore damaged tissue. Spiny mice of the genus Acomys represent the first example of full skin autotomy in mammals. Acomys cahirinus h...
ORGANISM(S): Mus musculus (Mouse) Acomys cahirinus 
2025-10-31 | PXD047626 | Pride
Proteomics Regeneration Tandem mass spectrometry Wound healing Matrisome Scar-free Fibrosis Acomys cahirinus Spiny mouse Extracellular matrix 
ProteomicsExtracellular Matrix Proteome of Aging-Specific Fibrotic Niche Cells in Mouse Liver Tissue
The extracellular matrix (ECM) is a complex network comprising hundreds of proteins, serving not only a structural role in shaping multicellular organisms but also participating in signaling processes. Moreover, the ECM exhibits high tissue specificity and undergoes significant alterations with agin...
ORGANISM(S): Mus musculus (Mouse) 
2025-02-13 | PXD060715 | Pride
Lc-ms/ms based proteomics Tandem mass tag (tmt) Senescence Extracellular matrix 
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