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ProteomicsA YTHDF-PABP axis is required for m6A-mediated organogenesis in plants
N6-methyladenosine (m6A) in mRNA is key to eukaryotic gene regulation. Many m6A functions involve RNA-binding proteins that recognize m6A via a YT521-B Homology (YTH) domain. YTH domain proteins contain long intrinsically disordered regions (IDRs) that may mediate phase separation and interaction wi...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-11-28 | PXD045801 | Pride
Arabidopsis Plants M6a Ect2 
ProteomicsIdentification of ECT2-containing protein complex
Cellular extracts from HeLa cells expressing FLAG-ECT2 were immunopurified with anti-FLAG affinity beads and eluted with FLAG peptide. The eluates were resolved on SDS/PAGE and silver stained, followed by mass spectrometric analysis.
ORGANISM(S): Homo Sapiens 
2021-06-29 | PXD026977 |
ProteomicsECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype and the lack of specific signature makes difficult the development of targeted therapeutic strategy. We previously found that PRICKLE1, an evolutionary conserved protein acting as a regulator of vertebrate development,...
ORGANISM(S): Homo sapiens (Human) 
2019-10-15 | PXD011253 | Pride
Lc-msms Therapeutic targets Triple negative breast cancer Signaling Interactome Prickle1 Ect2 
ProteomicsPhoshorylation regulated UBF1 and ECT2 Binding on ribosomal DNA
Epithelial Cell Transforming Sequence 2 (ECT2), a guanine nucleotide exchange factor (GEF) for Rho GTPases, is overexpressed in many cancers and is involved in signal transduction pathways that promote cancer cell proliferation, invasion and tumorigenesis. Recently, we demonstrated that a significan...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2020-04-10 | MSV000085269 | MassIVE
GenomicsRNA-seq of WT (Col-0) and ect2 in Arabidopsis
RNA-seq of WT (Col-0) and ect2 in Arabidopsis
PRJNA422492 | ENA
GenomicsFoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer
FoxM1 insufficiency hyperactivates Ect2-RhoA-mDia1 signaling to drive cancer
PRJNA540152 | ENA
GenomicsPrkci-Ect2 gain drives lung adenocarcinoma metastasis and lineage infidelity through enhanced cellular plasticity
Prkci-Ect2 gain drives lung adenocarcinoma metastasis and lineage infidelity through enhanced cellular plasticity
PRJNA1449433 | ENA
UnknownECT2 overexpression promotes the polarization of tumor-associated macrophages in hepatocellular carcinoma via the ECT2/PLK1/PTEN pathway.
Not available
S-EPMC7870664 | biostudies-literature
TranscriptomicsRNA-seq of WT (Col-0) and ect2 in Arabidopsis
RNA-seq of WT (Col-0) and ect2 to study the differentially expressed genes.
ORGANISM(S): Arabidopsis thaliana 
2018-06-21 | GSE108118 | GEO
UnknownThe dynamic behavior of Ect2 in response to DNA damage.
Not available
S-EPMC4830932 | biostudies-literature
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