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ProteomicsPRICKLE1
Identification of the protein associated to PRICKLE1. Components of the evolutionarily conserved developmental planar cell polarity (PCP) pathway were recently described to play a prominent role in cancer cell dissemination. However, the molecular mechanisms by which PCP molecules drive the spread o...
ORGANISM(S): Homo sapiens (Human) 
2022-03-02 | PXD003784 | Pride
Rictor Mink1 Prickle1 
ProteomicsECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer
Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype and the lack of specific signature makes difficult the development of targeted therapeutic strategy. We previously found that PRICKLE1, an evolutionary conserved protein acting as a regulator of vertebrate development,...
ORGANISM(S): Homo sapiens (Human) 
2019-10-15 | PXD011253 | Pride
Lc-msms Therapeutic targets Triple negative breast cancer Signaling Interactome Prickle1 Ect2 
GenomicsLoss of PRICKLE1 in the myometrium leads to reduced fertility, abnormal myometrial architecture, and aberrant extracellular matrix deposition in mice.
Loss of PRICKLE1 in the myometrium leads to reduced fertility, abnormal myometrial architecture, and aberrant extracellular matrix deposition in mice.
PRJNA1160169 | ENA
UnknownPRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders.
Not available
S-EPMC3849077 | biostudies-literature
TranscriptomicsLoss of PRICKLE1 in the myometrium leads to reduced fertility, abnormal myometrial architecture, and aberrant extracellular matrix deposition in mice.
Uterine leiomyomas (UL) are the most prevalent benign tumors of the female reproductive tract, originating from the myometrium and affecting up to 75% of reproductive-age women. Symptoms of UL include pelvic pain, pressure, dysmenorrhea, menorrhagia, anemia, and reproductive dysfunction. Currently, ...
ORGANISM(S): Mus musculus 
2025-03-13 | GSE276991 | GEO
UnknownPrickle1 regulates differentiation of frontal bone osteoblasts.
Not available
S-EPMC6303328 | biostudies-literature
UnknownECT2 associated to PRICKLE1 are poor-prognosis markers in triple-negative breast cancer.
Not available
S-EPMC6734648 | biostudies-literature
UnknownPRICKLE1 promotes gastric cancer metastasis by activating mTOR signaling.
Not available
S-EPMC8205837 | biostudies-literature
UnknownEstrogen receptor alpha mediated repression of PRICKLE1 destabilizes REST and promotes uterine fibroid pathogenesis.
Not available
S-EPMC11419101 | biostudies-literature
UnknownA de novo mutation in PRICKLE1 associated with myoclonic epilepsy and autism spectrum disorder.
Not available
S-EPMC6251753 | biostudies-literature
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