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ProteomicsThe β2-subunit of voltage-gated calcium channels inhibits cardiomyocyte hypertrophy through a channel-independent mechanism.
L-type voltage-gated calcium channels (LTCCs) regulate crucial physiological processes in the heart. They are composed of the Cav1 pore-forming subunit and the accessory subunits Cav, Cav2 and Cav. Cav is a cytosolic soluble protein that regulates channel trafficking and activity, but it also exerts...
ORGANISM(S): Rattus norvegicus (Rat) Rattus 
2021-09-09 | PXD016483 | Pride
L-type voltage-gated calcium channels  cav-subunit  cardiac hypertrophy  calpain  cardiomyocytes  calpastatin 
ProteomicsInteractome of the -subunit of L-type voltage-gated calcium channels in adult cardiomyocytes
In cardiomyocytes, Ca2+ influx through L-type voltage-gated calcium channels (LTCCs) following membrane depolarization regulates crucial Ca2+-dependent processes including duration and amplitude of the action potentials and excitation-contraction coupling. LTCCs are heteromultimeric proteins compose...
ORGANISM(S): Rattus rattus (Black rat) 
2021-12-14 | PXD021375 | Pride
Dstorm Ca2+ influx Proteomics L-type voltage-gated calcium channels (ltccs) Nano-environments of cav2 Pull-down Cardiomyocytes 
TranscriptomicsCrosstalk between the effects of extracellular vesicles (Evs) and TNF on U937 human monocyte cell line
Under physiological conditions, extracellular vesicles (EVs) are present simultaneously in the extracellular compartment together with cytokines. Thus, we hypothesized that EVs in combination with cytokines induce different responses of monocyte cells compared to EVs or cytokines alone. Human monocy...
ORGANISM(S): Homo sapiens 
2013-06-19 | E-GEOD-47897 | biostudies-arrayexpress
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