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ProteomicsInteractome of Eif4a2 in mouse embryonic stem cells
Cell fate transitions depend on balanced rewiring of transcription and translation programmes to enable ordered developmental progression. We identified a feedback loop between nonsense-mediated mRNA decay (NMD) and translation initiation, in which NMD controls the translation initiation factor Eif4...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-09 | PXD019588 | Pride
Mouse embryonic stem cells Eif4a2 
GenomicsRIP-Seq of Eif4a2 in mouse embryonic stem cell
RIP-Seq of Eif4a2 in mouse embryonic stem cell
PRJNA642755 | ENA
ProteomicseIF4A2 drives repression of translation at initiation by Ccr4-Not through purine rich motifs in th 5'UTR
Here we show eIF4A2 is a major effector of the represive miRNA pathway functioning via the Ccr4_Not complex; through its interaction with the Ccr4-Not complex eIF4A2 represses mRNAs at translation initiation. We show evidence that native eIF4A2 has similar properties to chemically inhibited eIF4A1...
ORGANISM(S): Homo sapiens (Human) 
2019-10-10 | PXD015772 | Pride
Translation Eif4a2 Initiation Ddx6 Mrna 
UnknownSumoylation of eIF4A2 affects stress granule formation.
Not available
S-EPMC4920252 | biostudies-literature
UnknownDEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity.
Not available
S-EPMC6736043 | biostudies-literature
UnknownCopy number variation of EIF4A2 loci related to phenotypic traits in Chinese cattle.
Not available
S-EPMC9514498 | biostudies-literature
OtherRIP-Seq of Eif4a2 in mouse embryonic stem cell
RNA-immunoprecipitation can be used to identify transcripts bound by RNA binding proteins. Here we identified transcripts bound by the translation initiation factor Eif4a2 in ESCs. We found that several pluripotency transcription factor encoding mRNAs and factors regulating ESC differentiation show ...
ORGANISM(S): Mus musculus 
2022-02-02 | GSE153456 | GEO
UnknownCritical and differential roles of eIF4A1 and eIF4A2 in B-cell development and function.
Not available
S-EPMC11685474 | biostudies-literature
GenomicseIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of embryonic and cancer stemness [Ribo-seq]
eIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of embryonic and cancer stemness [Ribo-seq]
PRJNA633140 | ENA
GenomicseIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of embryonic and cancer stemness [eCLIP-seq]
eIF4A2 targets developmental potency and histone H3.3 transcripts for translational control of embryonic and cancer stemness [eCLIP-seq]
PRJNA633144 | ENA
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