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ProteomicsHUWE1 interaction partners in HCT116 cells (TMT)
Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts, TRCs). TRCs can result in DNA damage and underlie genomic instability in tumor cells. Here we provide evidence that elongating RNAPII pro...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD037677 | Pride
Human Wrnip1 Hct116 Huwe1 
ProteomicsHUWE1 interaction partners in HCT116 cells (label free)
Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts, TRCs). TRCs can result in DNA damage and underlie genomic instability in tumor cells. Here we provide evidence that elongating RNAPII pro...
ORGANISM(S): Homo sapiens (Human) 
2023-07-31 | PXD037812 | Pride
Human Wrnip1 Hct116 Huwe1 
ProteomicspSer2-RNAPII interaction partners in MEF cells (label free)
Deregulation of RNA Polymerase II (RNAPII) by oncogenic signaling leads to collisions of RNAPII with DNA synthesis machinery (transcription-replication conflicts, TRCs). TRCs can result in DNA damage and underlie genomic instability in tumor cells. Here we provide evidence that elongating RNAPII pro...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-31 | PXD037680 | Pride
Ap-ms Mef Mouse Pser2-rnapii 
ProteomicsThe dimeric deubiquitinase Usp28 integrates 53bp1 and Myc functions to limit DNA damage
The oncogenic transcription factor Myc is a pleiotropic regulator of RNA Polymerase II (RNAPII)-dependent transcription, DNA replication and DNA damage response pathways. Myc is stringently regulated by the ubiquitin system - for example, ubiquitination controls recruitment of the elongation factor ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-09 | PXD037263 | Pride
Human Ap-ms Immunoprecipitation Usp28 53bp1 
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