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ProteomicsCF sputum LC-MSMS - Proteomic profile of cystic fibrosis sputum cells in adults chronically infected with Pseudomonas aeruginosa
Lung disease is the main cause of morbidity and mortality in cystic fibrosis (CF), and involves chronic infection by a destructive microbiota and perturbed innate and adaptive immune responses. Tissue damage is considered to be mediated mostly by proteases, but other bacterial and host factors may a...
ORGANISM(S): Homo sapiens (Human) 
2017-05-19 | PXD001985 | Pride
Lc-msms Sputum Cystic fibrosis 
UnknownRandomised, phase 1/2a trial of ION-827359, an antisense oligonucleotide inhibitor of ENaC.
Not available
S-EPMC11403593 | biostudies-literature
UnknownEfficacy and safety of ivacaftor in patients with cystic fibrosis who have an Arg117His-CFTR mutation: a double-blind, randomised controlled trial.
Not available
S-EPMC4641035 | biostudies-literature
TranscriptomicsElucidating the RamA Regulon in Klebsiella pneumoniae
Directional RNAseq analyses was undertaken in Klebsiella pneumoniae Ecl8 and isogenic mutants Ecl8delta ramA and Ecl8delta ramR to determine the RamA regulon. All samples were grown in Luria Bertani broth until OD600 approx 0.6 prior to RNA extraction. Differential expression was determined using DE...
ORGANISM(S): Klebsiella pneumoniae 
2014-08-15 | E-ERAD-122 | biostudies-arrayexpress
UnknownComparison of microbiomes from different niches of upper and lower airways in children and adolescents with cystic fibrosis.
Not available
S-EPMC4309611 | biostudies-literature
UnknownElucidation of the RamA regulon in Klebsiella pneumoniae reveals a role in LPS regulation.
Not available
S-EPMC4310594 | biostudies-literature
UnknownAntisense oligonucleotide eluforsen improves CFTR function in F508del cystic fibrosis.
Not available
S-EPMC7227803 | biostudies-literature
UnknownAnalysis of SARS-CoV-2 antibody seroprevalence in Northern Ireland during 2020-2021.
Not available
S-EPMC10830527 | biostudies-literature
UnknownEmpire-CF study: A phase 2 clinical trial of leukotriene A4 hydrolase inhibitor acebilustat in adult subjects with cystic fibrosis.
Not available
S-EPMC8649042 | biostudies-literature
UnknownProspective multicenter randomized patient recruitment and sample collection to enable future measurements of sputum biomarkers of inflammation in an observational study of cystic fibrosis.
Not available
S-EPMC6485181 | biostudies-literature
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