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TranscriptomicsTranscription profiling of pig endothelial cells from animials fed high or low cholesterol diet shows brief hypercholesterolemia induces side-specific protective changes in pig aortic valve endothelia
The study demonstrates (i) spatial heterogeneity of endothelial responses to hypercholesterolemia in the aortic valve, (ii) that endothelial metabolism is not dysfunctional in early focal lipid insudation, and (iii) that protective endothelial pathways induced by hypercholesterolemia may initially i...
ORGANISM(S): Sus scrofa 
2009-11-16 | E-CBIL-47 | biostudies-arrayexpress
TranscriptomicsCellular plasticity and diversity during heart valve epithelial-to-mesenchymal transitions revealed using single-cell RNA-seq
We have generated scRNA-seq data from embryonic day (E)10.5 and E12.5 atrioventricular canals (primitive heart valves) to assess cellular diversity during the distinct epithelial-to-mesenchymal transitions (EMTs) from endocardium and epicardium that guide the formation of valve mesenchyme. Alongside...
ORGANISM(S): Mus musculus 
2023-06-30 | E-MTAB-11795 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of left cardiac ventricle from rats with Aortic valve Regurgitation or sham operated rats
Compared Gene Expression Profiling of Rats with Aortic valve Regurgitation (AR) vs Sham operated Rats
ORGANISM(S): Rattus norvegicus 
2009-06-10 | E-TABM-490 | biostudies-arrayexpress
TranscriptomicsGenome-based approaches to understanding phosphorus deprivation responses and PSR1 control in Chlamydomonas reinhardtii.
The Chlamydomonas reinhardtii transcription factor PSR1 is required for the control of activities involved in scavenging phosphate from the environment during periods of phosphorus limitation. Increased scavenging activity reflects the development of high-affinity phosphate transport and the express...
ORGANISM(S): Chlamydomonas reinhardtii 
2006-08-18 | E-GEOD-4568 | biostudies-arrayexpress
ProteomicsHyalectan Remodeling Contributes to Aortic Stenosis: Insights from Glycoproteomics
BACKGROUND: Calcific aortic valve disease (CAVD) is increasingly recognized as an active pathological process involving extracellular matrix (ECM) remodeling. This study investigates ECM remodeling through proteomic analysis and a novel mouse model of aortic stenosis (AS). METHODS: Proteomic and gly...
ORGANISM(S): Homo sapiens (Human) 
2026-07-16 | PXD078618 | Pride
Adamts Proteoglycan Calcific aortic valve disease Aortic stenosis Extracellular matrix 
ProteomicsDinitrogenase functionality in Cyanothece 51142 during nutrient limitation
Dinitrogenase functions as an electron valve to prevent ROS in Cyanothece 51142 during nutrient limitation
ORGANISM(S): Cyanothece sp. (strain ATCC 51142) 
2018-10-24 | PXD002841 | Pride
Dinitrogenase Nutrient Electron valve 
GenomicsProfiling Genome-Wide DNA Methylation Patterns in Human Aortic and Mitral Valves
Cardiac valve structure and function are complex and include dynamic interactions between cells, extracellular matrix (ECM) and their hemodynamic environment. Valvular gene expression is tightly regulated by a variety of mechanisms including epigenetic factors such as histone modifications, RNA-base...
EGAS00001004559 | EGA
ProteomicsAortic Aneurysm iTRAQ HiRIEF proteomics
Conducted proteomics on samples from patients with aortic aneurysm and from non-dilated controls. Furthermore, we investigated both patients with bicuspid aortic valves (BAV) and also the more normal tricuspid aortic valves (TAV). The aim was to elucidate the molecular mechanisms behind the higher p...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080837 | MassIVE
TranscriptomicsTranscription profiling of endothelial cells from opposite sides of aortic valves from healthy adult male pigs
Differential transcriptional profiles from endothelial cells isolated from opposite sides of aortic valves from healthy adult male pigs (N=8, from slaughterhouse). Samples were hybridized to a human array and paired by animal.
ORGANISM(S): Sus scrofa 
2007-07-14 | E-CBIL-32 | biostudies-arrayexpress
ProteomicsProtein profiling of left ventricular tissue of patients with aortic valve disease
We aimed to disclose specific LV myocardial protein signatures possibly contributing to differential disease progression after aortic valve surgery in patients with chronic aortic stenosis and patients with chronic aortic regurgitation.
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD039662 | Pride
Aortic valve disease Dia Human Left ventricular tissue Lc-ms/ms 
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