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GenomicsIntegrative Analyses of Gene Expression and DNA Methylation Profiles in a Breast Cancer Cell Line Model of Tamoxifen-Resistance Indicate a Crucial Role of Cells with Stem-like Properties
Purpose: Development of resistance to tamoxifen is an important clinical issue in the treatment of patients with breast cancer. Tamoxifen resistance may be the result of the acquisition of epigenetic regulation such as DNA methylation within breast cancer cells resulting in changed mRNA expression o...
ORGANISM(S): Homo sapiens 
2014-02-03 | E-GEOD-40665 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptome analysis of B. burgdorferi during adherence and invasion of human neuroglial cells
As adherence and entry of a pathogen into a host cell are two key components to an infection, identifying the molecular mechanisms responsible for cellular association will provide a better understanding of a microbe’s ability for pathogenesis. We previously established an in vitro model for B. b...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-8219 | biostudies-arrayexpress
ProteomicsUBE2O remodels the proteome during terminal erythroid differentiation
Terminal differentiation is characterized by a respecification of the global protein complement, as epitomized by erythrocytes, whose cytosol is ~98% globin. Remodeling of the proteome involves programmed elimination of generic cellular constituents in parallel with synthesis of cell-type-specific p...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2017-08-08 | PXD005904 | Pride
Red blood cell Proteomics Ms3 Tmt Ube2o Proteasome Ubiquitin 
ProteomicsLysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation
Recent studies have shown that lysines can be posttranslationally modified by various types of acylations. However, except for acetylation, very little is known about their scope and cellular distribution. We mapped thousands of succinylation sites in bacteria (E. coli), yeast (S. cerevisiae), human...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2015-06-02 | PXD002277 | Pride
Yeast Human Liver Bacteria Mouse Succinylation Acetylation 
UnknownRhythmic Relating: Bidirectional Support for Social Timing in Autism Therapies.
Not available
S-EPMC9186469 | biostudies-literature
UnknownImproving Transplant-free Survival With Low-volume Plasma Exchange to Treat Children With Rodenticide Induced Hepatotoxicity.
Not available
S-EPMC10025587 | biostudies-literature
TranscriptomicsmiR-155 regulates the ability of circulating cancer cells to colonize and establish metastasis
Abstract: Metastases are established through a complex multistep process by which tumor cells disseminate from the primary tumor and expand at distant sites. Traditionally, studies on metastasis have focused on proteins and protein-coding genes, but recently microRNAs (miRNAs) have achieved increasi...
ORGANISM(S): Homo sapiens 
2012-05-02 | E-GEOD-37719 | biostudies-arrayexpress
TranscriptomicsGene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics [Expression]
From a clinical and molecular perspective, colon cancer (CC) is a heterogeneous disease but to date no classification based on high-density transcriptome data has been established. The aim of this study was to build up a robust molecular classification of mRNA expression profiles (Affymetrix U133Pl...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-39582 | biostudies-arrayexpress
TranscriptomicsGene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics [CGH]
From a clinical and molecular perspective, colon cancer (CC) is a heterogeneous disease but to date no classification based on high-density transcriptome data has been established. The aim of this study was to build up a robust molecular classification of mRNA expression profiles (Affymetrix U133Pl...
ORGANISM(S): Homo sapiens 
2013-05-22 | E-GEOD-40966 | biostudies-arrayexpress
GenomicsOxford nanopore sequencing data from the Arabidopsis thaliana accessions Ler-0, Cvi-0 and Tanz-1
Oxford nanopore sequencing data from the Arabidopsis thaliana accessions Ler-0, Cvi-0 and Tanz-1
ORGANISM(S): Arabidopsis thaliana 
2022-08-06 | E-MTAB-12009 | biostudies-arrayexpress
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