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TranscriptomicsPlacental infection single-cell and single-nuclei maps
This resource comprises a single-cell multi-lineage map of first trimester infected placental cells. We have included data from both uninfected cells and cells infected with three pathogens known to cause maternal and fetal disorders: Plasmodium falciparum, Listeria monocytogenes, and Toxoplasma gon...
ORGANISM(S): Homo sapiens 
2024-03-01 | E-MTAB-12795 | biostudies-arrayexpress
TranscriptomicsExpression signatures of human HeLa cells with RNAi targetting A1 hnRNP, FUS, H hnRNP and p68-DDX5
Transcription profiling of human HeLa cells (cervical cancer cell line) transfected with a plasmid expressing shRNAs cloned into the pSuper expression vector compared to emprty vector negative controls for transfection. Four different RNA interference treatments targetted: A1 hnRNP (HNRNPA1, Heterog...
ORGANISM(S): Homo sapiens 
2008-08-20 | E-GEOD-12058 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling of tamoxifen sensitive and resistant ER+ breast cancer cell lines
Tamoxifen is an effective anti-estrogen treatment for patients with estrogen receptor-positive (ER+) breast cancer. However, about 30% of such patients receiving tamoxifen as an adjuvant therapy experience recurrence within 15 years, and most patients with advanced disease eventually develop resista...
ORGANISM(S): Homo sapiens 
2015-08-01 | E-GEOD-56411 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of human ex-vivo skin samples with variable skin color types
Global gene expression profile from skin of variable pigmentation to identify new biological pathways which could be involved in the pigmentation phenotype. We performed a next generation NGS RNA sequencing study on ex vivo epidermis with different levels of pigmentation. We used the ITA to define...
ORGANISM(S): Homo sapiens 
2025-12-30 | E-MTAB-15371 | biostudies-arrayexpress
TranscriptomicsGlobal transcriptome analysis of B. burgdorferi during adherence and invasion of human neuroglial cells
As adherence and entry of a pathogen into a host cell are two key components to an infection, identifying the molecular mechanisms responsible for cellular association will provide a better understanding of a microbe’s ability for pathogenesis. We previously established an in vitro model for B. b...
ORGANISM(S): Homo sapiens 
2010-05-26 | E-GEOD-8219 | biostudies-arrayexpress
ProteomicsGenetic and proteomic screens reveal perturbed nucleotide metabolism and DNA-protein crosslink formation as central mediators of decitabine cytotoxicity
Decitabine (5-aza-dC) is a DNMT1-DPC inducing agent used to treat several hematological cancers. However, response rates vary, relapse is common, and predictive biomarkers are unknown. Here, we develop an adaptation of identification of proteins on nascent DNA (iPOND) by combining EdU with 5-aza-dC ...
ORGANISM(S): Homo sapiens (Human) 
2024-04-18 | PXD045071 | Pride
Decitabine Dna-protein crosslink Topors Global-genome dpc repair Dna methylation Sumo Dnmt1 
TranscriptomicsTonsil Atlas FASTQ files
This repository contains all the FASTQ files for the five data modalities (scRNA-seq, scATAC-seq, Multiome, CITE-seq+scVDJ-seq, and spatial transcriptomics) used in the article \\"An Atlas of Cells in The Human Tonsil,\\" published in Immunity in 2024. Inspired by the TCGA barcodes, we have named ea...
ORGANISM(S): Homo sapiens 
2024-05-02 | E-MTAB-13687 | biostudies-arrayexpress
UnknownEx-vivo sensitivity profiling to guide clinical decision making in acute myeloid leukemia: A pilot study.
Not available
S-EPMC5756519 | biostudies-literature
UnknownPhysiological blood-brain transport is impaired with age by a shift in transcytosis.
Not available
S-EPMC8331074 | biostudies-literature
UnknownHydroxychloroquine in mild-to-moderate coronavirus disease 2019: a placebo-controlled double blind trial.
Not available
S-EPMC8015393 | biostudies-literature
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