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xref:PubMed:39198401 (2)

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Proteome data on human MDS-L cells

Shotgun mass spectrometric analysis of WT and TOPORS KO MDS-L cells

ORGANISM(S): Homo Sapiens (human)

2024-03-08 | PXD048275 | JPOST Repository

Concerted SUMO-targeted ubiquitin ligase activities of TOPORS and RNF4 are essential for stress management and cell proliferation

Protein SUMOylation provides a principal driving force for cellular stress responses including DNA-protein crosslink (DPC) repair and arsenic-induced PML body degradation. In this study, using genome-scale screens, we identify the human E3 ligase TOPORS as a key effector of SUMO-dependent DPC resolu...

ORGANISM(S): Homo sapiens (Human)

2024-04-11 | PXD041717 | Pride