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TranscriptomicsMicroRNA expression profiling of human pancreatic islets reveals microRNAs with altered expression due to glyceamic status
Global microRNA (miRNA) profiling was performed in 18 human islet donors using Exiqon’s LNA (locked nucleic acid)-based array platform. Donors were divided into three groups according to their HbA1c levels and type-2 diabetes diagnosis (normal glucose tolerance - NGT, impaired glucose tolerance - IG...
ORGANISM(S): Homo sapiens 
2022-02-28 | E-MTAB-11125 | biostudies-arrayexpress
UnknownSingle Fusion Pore Analysis via Single Cell Amperometry Uncovers Impaired Pore Expansion That Restricts Insulin Exocytosis in Human Type 2 Diabetes.
Not available
S-EPMC12603977 | biostudies-literature
ProteomicsProteoglycan profiling of human, rat and mouse insulin-secreting cells
Proteoglycans (PGs) are proteins with glycosaminoglycan (GAG) chains, such as chondroitin sulfate (CS) or heparan sulfate (HS), attached to serine residues. We have earlier shown that prohormones can carry CS, thus, constituting a novel class of PGs. The mapping of GAG modifications of proteins in e...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) Rattus norvegicus (Rat) 
2022-02-16 | PXD024230 | Pride
Glycosaminoglycan Insulinoma islet cells Chromogranin-a Insulin Proteoglycan 
TranscriptomicsAnalysis of sex differences in DNA methylation in human pancreatic islets
Epigenetic factors regulate tissue-specific expression and X-chromosome inactivation. Previous studies have identified epigenetic differences between sexes in some human tissues. However, it is unclear whether epigenetic modifications contribute to sex-specific differences in insulin secretion and m...
ORGANISM(S): Homo sapiens 
2014-10-24 | E-GEOD-62640 | biostudies-arrayexpress
TranscriptomicsArgonaute2 mediates compensatory expansion of the pancreatic M-CM-^_-cell
Pancreatic M-CM-^_-cells adapt to compensate for the increased metabolic demand during insulin resistance. While the microRNA pathway has an essential role in the expansion of M-CM-^_-cell mass, the extent of its contribution is unclear. Here we show that miR-184 is silenced in the pancreatic islets...
ORGANISM(S): Mus musculus 
2014-02-06 | E-GEOD-46623 | biostudies-arrayexpress
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