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ProteomicsStructural analysis of the PTEN:P-Rex2 signaling node reveals how cancer-associated mutations coordinate to hyperactivate Rac1
The PTEN:P-Rex2 complex is a commonly mutated signaling nodes in metastatic cancer. The dual-specificity phosphatase PTEN canonically functions as a tumour suppressor by hydrolysing PI(3,4,5)P3 to PI(4,5)P2 to inhibit PI3K-AKT signaling. P-Rex2 is a RhoGTPase guanine nucleotide exchange factor activ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD021126 | Pride
Cancer P-rex2 Pten Crosslinking mass spectrometry Metastasis 
ProteomicsStructural analysis of neurofibromin by crosslinking mass spectrometry
Neurofibromin (NF1) is a fundamental inhibitor of cell growth that is conserved from yeast to humans. NF1 negatively regulates oncogenic RAS proteins by accelerating the hydrolysis of RAS-bound GTP. This activity blocks growth factor signalling upstream of both mitogen-activated protein kinase (MAPK...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD023593 | Pride
Cancer Neurofibromin Tumour-suppressor protein 
ProteomicsStructure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism
Rho GTPases regulate actin dynamics and cell motility, and their hyperactivation drives cancer metastasis1. P-Rex (PI(3,4,5)P3-dependent Rac Exchanger) guanine nucleotide exchange factors (GEFs) are potent on-switches for Rho GTPase signalling and are frequently dysregulated in metastatic cancer2. P...
ORGANISM(S): Homo sapiens (Human) 
2022-08-12 | PXD034327 | Pride
Cancer Rac1 Cryo-em P-rex1 Metastasis 
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