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ProteomicsIntegrated proteomics spotlight the proteasome as a pervasive therapeutic vulnerability in Embryonal Tumors with Multilayered Rosettes (ETMR)
Embryonal tumors with multilayered rosettes (ETMR) are rare malignant embryonal brain tumors. The prognosis of ETMR is poor and novel therapeutic approaches are desperately needed. Comprehension of ETMR tumor biology is based on only few previous molecular studies, which mainly relied on the analyse...
ORGANISM(S): Homo sapiens (Human) 
2024-01-08 | PXD045268 | Pride
Transcriptome Multiomics Embryonal tumor with multilayered rosettes Mass spectrometry 850k Methylome Etmr Embryonal brain tumor Lin28a Dna methylation Proteome 
UnknownTranscriptomic Analysis Revealed an Emerging Role of Alternative Splicing in Embryonal Tumor with Multilayered Rosettes.
Not available
S-EPMC7563716 | biostudies-literature
UnknownIntegrated proteomics spotlight the proteasome as a therapeutic vulnerability in embryonal tumors with multilayered rosettes.
Not available
S-EPMC11066909 | biostudies-literature
UnknownCellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor-ligand interactions.
Not available
S-EPMC12202505 | biostudies-literature
UnknownA novel C19MC amplified cell line links Lin28/let-7 to mTOR signaling in embryonal tumor with multilayered rosettes.
Not available
S-EPMC3870842 | biostudies-literature
UnknownPotential Importance of Early Focal Radiotherapy Following Gross Total Resection for Long-Term Survival in Children With Embryonal Tumors With Multilayered Rosettes.
Not available
S-EPMC7773839 | biostudies-literature
TranscriptomicsA mouse model for embryonal tumors with multilayered rosettes uncovers the therapeutic potential of Sonic-hedgehog inhibitors
Embryonal Tumors with Multilayered Rosettes (ETMRs) have recently been described as a new entity of rare pediatric brain tumors with fatal outcome. We show here that ETMRs are characterized by a parallel activation of Shh- and Wnt-signaling. Co-activation of these pathways in murine neural precursor...
ORGANISM(S): Mus musculus 
2017-09-11 | GSE103348 | GEO
UnknownTargeted radioimmunotherapy for embryonal tumor with multilayered rosettes.
Not available
S-EPMC7416633 | biostudies-literature
GenomicsPotential importance of early focal radiotherapy following gross total resection for long-term survival in children with embryonal tumors with multilayered rosettes (ETMR)
Potential importance of early focal radiotherapy following gross total resection for long-term survival in children with embryonal tumors with multilayered rosettes (ETMR)
PRJNA674910 | ENA
UnknownEmbryonal tumor with multilayered rosettes: Overview of diagnosis and therapy
Not available
S-EPMC10506690 | biostudies-literature
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