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TranscriptomicsGenes regulated in EML1 cells expressing the TEL-AML1 oncogene after 5 and 7 days of treatment with IL7 and FLT3 ligand.
The t(12;21) translocation is the most common genetic rearrangement in childhood acute lymphoblastic leukemia (ALL) and gives rise to the TEL-AML1 fusion gene, which functions as a transcription factor. TEL-AML1 expression in EML1 cells results in an impairment of differentiation along the B-lymphoi...
ORGANISM(S): Mus musculus 
2015-05-13 | E-GEOD-64919 | biostudies-arrayexpress
ProteomicsEmbryonic cortical extract mass spectrometry to identify EML1 interactors
The cerebral cortex is a highly organized structure whose development depends on different progenitor cell types. These give rise to post-mitotic neurons that migrate across the developing cortical wall to their final positions in the cortical plate. Apical radial glia cells (aRGs) are the main prog...
ORGANISM(S): Mus musculus (Mouse) 
2019-06-20 | PXD012714 | Pride
Development Mass spectrometry Neocortex Murine Eml1 
ProteomicsEml1-associated proteins in mouse neural progenitors
Echinoderm microtubule (MT)-associated protein-like 1 (Eml1) is mutated in the HeCo mouse, which exhibits subcortical band heterotopia (SBH), a developmental malformation of the cerebral cortex. EML1 mutations are also found in human patients affected by severe ribbon-like heterotopia, associated wi...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-19 | PXD006837 | Pride
Neural progenitors Mouse Microtubules Eml1 Cortical development 
ProteomicsForebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia
The layered structure of the cerebral cortex is formed through a complicated sequence of highly controlled stages during corticogenesis. The perturbation of neuronal migration and cell division during this process can result a rare disorder called as cortical heterotopia. EML1 is a heterotopia assoc...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-26 | PXD045846 | Pride
Cell line Mouse Bioid Eml1 
ProteomicsLoss of Eml1 alters microtubule-associated protein networks in mouse brain heterotopia
The layered structure of the cerebral cortex is formed through a complicated sequence of highly controlled stages. During this process, the perturbations of neuronal migration and cell division can result in a rare disorder called cortical heterotopia. Heterotopia patients can have recurrent epilept...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-07 | PXD052486 | Pride
Cortical development Microtubules (mts) Microtubule-associated proteins (maps) Cortical malformation Eml1 Proteomics 
UnknownEML1 is essential for retinal photoreceptor migration and survival.
Not available
S-EPMC8861151 | biostudies-literature
GenomicsHuman iPSC-derived cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation
Human iPSC-derived cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation
PRJNA801685 | ENA
UnknownForebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia.
Not available
S-EPMC11450323 | biostudies-literature
GenomicsGenome-wide EML1 binding sites in Arabidopsis thaliana seedlings
To identify genomic targets involved in the EML-dependent control of seed development, we performed ChIP-chip using whole genome Arabidopsis tiling arrays from p35S::EML1-GFP seedlings using GFP antibodies. The analysis showed that EML1 displayed preferential binding to transposable elements (TEs), ...
ORGANISM(S): Arabidopsis thaliana 
2021-04-23 | GSE98977 | GEO
UnknownHuman cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation.
Not available
S-EPMC9066063 | biostudies-literature
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