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TranscriptomicsHuman-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion
The evolutionary expansion of the human neocortex reflects increased amplification of basal progenitors in the subventricular zone, producing more neurons during fetal corticogenesis. Here, we analyze the transcriptomes of distinct progenitor subpopulations isolated by a novel approach from developi...
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-65000 | biostudies-arrayexpress
TranscriptomicsTranscriptomes of germinal zones of human and mouse fetal neocortex suggest a role of extracellular matrix in progenitor self-renewal.
The expansion of the neocortex during mammalian brain evolution results primarily from an increase in neural progenitor cell divisions in its two principal germinal zones during development, the ventricular zone (VZ) and the subventricular zone (SVZ). Using mRNA sequencing, we analyzed the transcrip...
ORGANISM(S): Homo sapiens 
2012-07-02 | E-GEOD-38805 | biostudies-arrayexpress
TranscriptomicsBulk RNA-seq of the human fetal neocortex, lateral ganglionic eminence and medial ganglionic eminence at 7, 9, 11 and 20 post-conceptional weeks
Deep transcriptional profiling of the human neocortex, lateral ganglionic eminence (LGE) and medial ganglionic eminences (MGE), from 7 to 20 post-conceptional weeks (pcw), for de novo lincRNAs discovery and to establish a unique coding and non-coding gene signature for the three different regions.
ORGANISM(S): Homo sapiens 
2021-05-13 | E-MTAB-8893 | biostudies-arrayexpress
TranscriptomicsDifferentially expressed genes among motor and prefrontal areas of macaque monkey neocortex
Motor-related areas of neocortex are highly differentiated into several subareas from both functional and cytoarchitectural aspects in the higher primates. To assess the molecular basis of such areal specialization, we investigated the gene expression profiles of primary motor area (M1), premotor ar...
ORGANISM(S): Macaca mulatta 
2007-08-31 | E-GEOD-8644 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse neocortical neural precursor cells incubated with Wnt3a for 0,3,6 and 12 hours
Microarray analysis for the identification of the downstream targets of Wnt signaling in the developing neocortex.
ORGANISM(S): Mus musculus 
2010-02-26 | E-TABM-923 | biostudies-arrayexpress
ProteomicsImpact of anesthetics on rat hippocampus and neocortex: a comprehensive proteomic study based on label-free mass spectrometry
In this work, in vivo experiment simulating a general anesthesia and ICU sedation was designed to assess the impact of two intravenous (midazolam, dexmedetomidine) and two inhalational (isoflurane, desflurane) agents to neuronal centers for cognition (neocortex), learning, and memory (hippocampus). ...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-23 | PXD045159 | Pride
Hippocampus Neocortex Long-term potentiation Anesthetics Gaba signaling Vdac Apoptosis Nmdar Label-free proteomics 
TranscriptomicsGenome-wide profiling of altered gene expression in the neocortex of Alzheimer's disease (gene level)
We investigated genome-wide gene alterations in the temporal cortex of a well-characterized cohort of AlzheimerM-bM-^@M-^Ys disease (AD) patients using Affymetrix exon arrays. The AD patients and controls are subjects originally recruited into OPTIMA (Oxford Project to Investigate Memory and Ageing)...
ORGANISM(S): Homo sapiens 
2012-04-12 | E-GEOD-37263 | biostudies-arrayexpress
ProteomicsProtein solubility changes in mouse neocortex during aging.
Protein solubility changes in mouse neocortex during aging.
ORGANISM(S): Mus musculus (Mouse) 
2026-02-23 | PXD057311 | Pride
Protein solubility  insolubilome  proteostasis  aging  protein quality control  mouse. 
ProteomicsHuman temporal neocortex brain LC-MS
We used label-free shotgun mass spectrometry to analyze temporal neocortex samples from AD brain, other neurological disorders and non-demented controls, in order to identify additional proteins thatare altered in AD. The mass spectrometry results were then verified by antibody suspension bead arra...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD004499 | Pride
Alzheimer’s disease  mass spectrometry  antibodies Immobilized/chemistry  extracellular vesicles  exosomes  exocytosis  endocytosis. 
TranscriptomicsExpression data from neurospheres derived from the neocortex, striatum and subventricular zones of the adult mouse brain
Differential gene expression profiles of neurospheres derived from different regions of the adult brain. In this dataset, we include data on triplicated biological samples from each of the following brain regions: neocortex, striatum, and subventricular zone. We also include duplicated data on neur...
ORGANISM(S): Mus musculus 
2013-10-01 | E-GEOD-49194 | biostudies-arrayexpress
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