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ProteomicsNUDT2 Knockout full proteome mouse
Proteome comparison between bone-marrow cells isolated from wildtype and NUDT2 knockout mice.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD023219 | Pride
Mouse Full proteome Lc-ms Nudix hydolases Bone-marrow 
ProteomicsMDM2 influences ACE2 stability and SARS-Cov2 uptake
The Angiotensin-converting enzyme 2 (ACE2) receptor is the central entry point for SARS-Cov2. Several SAR-Cov2 substrains have developed mutations in their spike protein to maximize their use of ACE2, e.g. to strengthen ACE2 binding for increased uptake or adapt to specific amino acid properties of ...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2023-09-08 | PXD040891 | Pride
Human Ubiquitination Sars-cov2 Ace2 
ProteomicsMultilevel proteomics reveals common and specific host perturbations by Monkeypox and Vaccinia viruses
The global spread of Monkeypox virus (MPXV) has resulted in the urgent need for an in-depth molecular characterization of the virus infection. Multiple omics studies on Vaccinia virus have extended our knowledge of poxvirus pathophysiology (REFs). Nevertheless, there are no comparative studies that ...
ORGANISM(S): Homo sapiens (Human) Monkeypox virus Orthopoxvirus 
2024-07-25 | PXD040889 | Pride
Human Poxvirus Lc-ms Monkeypoxvirus 
ProteomicsMultilevel proteomics reveals common and specific host perturbations by Monkeypox and Vaccinia viruses (full proteome)
The global spread of Monkeypox virus (MPXV) has resulted in the urgent need for an in-depth molecular characterization of the virus infection. Multiple omics studies on Vaccinia virus have extended our knowledge of poxvirus pathophysiology (REFs). Nevertheless, there are no comparative studies that ...
ORGANISM(S): Homo sapiens (Human) Monkeypox virus Orthopoxvirus 
2024-07-25 | PXD040811 | Pride
Human Poxvirus Shotgun-proteomics Vaccinia virus Monkeypox virus 
ProteomicsZika virus remodelled ER membranes contain an array of proviral factors involved in redox pathways
Zika virus (ZIKV) has emerged as a global health issue, yet neither antiviral therapy nor vaccine are available. ZIKV is an enveloped RNA virus, replicating in the cytoplasm in close association with ER membranes with the help of host cell factors that are poorly characterized. Here, we isolated ER ...
ORGANISM(S): Homo sapiens (Human) 
2023-11-14 | PXD043372 | Pride
Endoplasmatic reticulum Zika Redox pathway 
ProteomicsIKKα dependent activation of the β-catenin pathway is required for endosomal maturation and SARS-CoV-2 entry
COVID-19 is a complex disease characterized by fulminant replication of SARS-CoV-2 and associated virus-induced comorbidities. While the virus impedes induction and activity of host-protective antiviral processes, it at the same time induces exacerbated expression and function of NF-κB dependent inf...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Homo sapiens (Human) 
2026-08-03 | PXD036627 | Pride
Nfkb Sars-cov-2 Phosphoproteomics Shotgun proteomics 
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