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TranscriptomicsTRIM28 silences endogenous retroviruses in neural progenitor cells
Here we show that in neural progenitor cells (NPCs) TRIM28 silences transcription of two groups of endogenous retroviruses (ERVs): IAP1 and MMERVK10C. Derepression of ERVs in Trim28-deficient NPCs was associated with a loss of H3K9me3 and resulted in transcriptional upregulation and reverse transcri...
ORGANISM(S): Mus musculus 
2015-01-07 | E-GEOD-45930 | biostudies-arrayexpress
GenomicsCritical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency (Chip-Seq)
We recently showed that some human induced pluripotent stem cell (iPSC) clones were defective in neural differentiation and were marked with the activation of long term repeats (LTRs) of human endogenous retroviruses (HERVs). We herein demonstrated that these LTRs were transiently overexpressed duri...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-56567 | biostudies-arrayexpress
TranscriptomicsCritical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency (RNA-Seq)
We recently showed that some human induced pluripotent stem cell (iPSC) clones were defective in neural differentiation and were marked with the activation of long term repeats (LTRs) of human endogenous retroviruses (HERVs). We herein demonstrated that these LTRs were transiently overexpressed duri...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-56568 | biostudies-arrayexpress
ProteomicsMorc3 silences endogenous retroviruses by enabling Daxx-mediated histone H3.3 incorporation
Endogenous retroviruses (ERVs) comprise a significant portion of mammalian genomes. Although specific ERV loci feature regulatory roles for host gene expression, most ERV integrations are transcriptionally repressed by Setdb1 mediated H3K9me3 and DNA methylation. However, the protein network which r...
ORGANISM(S): Mus musculus (Mouse) 
2021-11-03 | PXD027368 | Pride
Morc3 Endogenous retroviruses Erv Histone h3.3 Daxx Setdb1 
TranscriptomicsSETDB1 Represses Endogenous and Exogenous Retroviruses in B Lymphocytes [RNA-Seq]
Genome stability relies on epigenetic mechanisms that enforce repression of endogenous retroviruses (ERVs). Current evidence suggests that distinct chromatin-based mechanisms repress ERVs in cells of embryonic origin (histone methylation-dominant) versus more differentiated cells (DNA methylation-do...
ORGANISM(S): Mus musculus 
2015-07-03 | E-GEOD-69464 | biostudies-arrayexpress
ProteomicsEndogenous retroviruses promote prion-like spreading of proteopathic seeds
Prion-like spreading of protein misfolding is characteristic for neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates that endogenous retroviruses, remnants of viral germline infections that are normally epigene...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-18 | PXD043201 | Pride
N2a Prion Retrovirus 
TranscriptomicsCritical role of transient activation of human endogenous retroviruses during reprogramming toward pluripotency
We recently showed that some human induced pluripotent stem cell (iPSC) clones were defective in neural differentiation and were marked with the activation of long term repeats (LTRs) of human endogenous retroviruses (HERVs). We herein demonstrated that these LTRs were transiently overexpressed duri...
ORGANISM(S): Homo sapiens 
2014-08-04 | E-GEOD-54848 | biostudies-arrayexpress
GenomicsHijacking of transcriptional condensates by endogenous retroviruses
Hijacking of transcriptional condensates by endogenous retroviruses
PRJNA669013 | ENA
ProteomicsHijacking of transcriptional condensates by endogenous retroviruses
Heterochromatin plays essential roles in repressing retrotransposons, e.g. endogenous retroviruses (ERVs) during mammalian development, but the contribution of retrotransposition to lethality observed in embryonic cells deficient for heterochromatin-mediated ERV repression is poorly understood. Here...
ORGANISM(S): Mus musculus (Mouse) 
2022-07-08 | PXD021895 | Pride
Transposable elements Heterochromatin Transcriptional condensates 
GenomicsSetdb1 is required for persistence of H3K9me3 and repression of endogenous retroviruses in mouse primordial germ cells
Transcription of endogenous retroviruses (ERVs) is inhibited by de novo DNA methylation during gametogenesis, a process initiated after birth in oocytes and at ~E15.5 in prospermatogonia. Earlier in germline development however, the genome, including most retrotransposons, is progressively demethyla...
ORGANISM(S): Mus musculus 
2014-09-01 | E-GEOD-60377 | biostudies-arrayexpress
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