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ProteomicsFlap endonuclease 1 repairs DNA-protein crosslinks via ADP-ribosylation
The protein composition of DNA-protein crosslinks (DPCs) induced by formaldehyde treatment of human cell lines was analyzed by mass spectrometry.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-06-14 | MSV000095039 | MassIVE
TranscriptomicsRequirement for flap endonuclease 1 (FEN1) to maintain genomic stability and transcriptional gene silencing in Arabidopsis
As a central component during Okazaki fragment maturation, flap endonuclease 1 (FEN1) removes the 5’ flap and maintains genomic stability. Here, FEN1 was cloned as a suppressor of transcriptional gene silencing (TGS) from a forward genetic screen. FEN1 is abundant in the root and shoot apical meri...
ORGANISM(S): Arabidopsis thaliana 
2016-05-28 | E-GEOD-79738 | biostudies-arrayexpress
TranscriptomicsOryza sativa ssp. indica Illumina libraries of the method plant-RRBS used for methylome profiling
The contained data consist of Illumina HiSeq 2500 reads generated from restriction endonuclease digested genomic DNA of Oryza sativa ssp. indica used as proof of concept for plant-RRBS methylome profiling by bioinformatics analyses. Five biological repeats for an inbred control line and a derived ep...
ORGANISM(S): Oryza sativa Indica Group 
2017-12-14 | E-MTAB-4626 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression after induction of DNA endonuclease
Investigating the induction of the SOS response after the introduction of a single dsDNA break per genome by expressing an endonuclease. The endonuclease is under the control of a xylose-inducible promoter.
ORGANISM(S): Bacillus subtilis 
2008-11-21 | GSE13544 | GEO
GenomicsEndonuclease enrichment TAPS for cost-effective genome-wide base-resolution DNA methylation detection
Endonuclease enrichment TAPS for cost-effective genome-wide base-resolution DNA methylation detection
PRJNA623426 | ENA
ProteomicsGABPA recruits the Integrator endonuclease complex to promote transcription elongation
Transcription factors (TFs) coordinate gene regulatory programs essential for cell identity, yet how individual TFs modulate distinct steps of transcription cycle remains incompletely understood. GA-binding protein alpha (GABPA), an erythroblast transformation specific (ETS)-family TF, is crucial fo...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-04 | PXD068470 | Pride
Intac Gabpa Transcription elongation 
GenomicsIdentification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease
Identification and characterization of small molecule inhibitors of the LINE-1 retrotransposon endonuclease
PRJNA1022033 | ENA
GenomicsINTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II
INTAC endonuclease and phosphatase modules differentially regulate transcription by RNA polymerase II
PRJNA925487 | ENA
TranscriptomicsGlobal analysis of mRNA decay intermediates in Saccharomyces cerevisiae
The general pathways of eukaryotic mRNA decay occur via deadenylation followed by 3’ to 5’ degradation or decapping, although some endonuclease sites have been identified in metazoan mRNAs. To determine the role of endonucleases in mRNA degradation in Saccharomyces cerevisiae, we mapped 5’ monophosp...
ORGANISM(S): Saccharomyces cerevisiae 
2012-06-17 | E-GEOD-33712 | biostudies-arrayexpress
GenomicsINTAC endonuclease and phosphatase modules have distinct roles in transcription (ChP-Seq)
INTAC endonuclease and phosphatase modules have distinct roles in transcription (ChP-Seq)
PRJNA925664 | ENA
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