Sort   by:  
 Page size 
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1969 | MetaboLights
MetabolomicsECM deposition is driven by caveolin1-dependent regulation of exosomal biogenesis and cargo sorting

The composition and physical properties of the extracellular matrix (ECM) critically influence tumor progression, but the molecular mechanisms underlying ECM layering are poorly understood. Tumor-stroma interaction is critically dependent on cell-cell communication mediated by exosomes, small ves...

2020-10-07 | MTBLS1977 | MetaboLights
ProteomicsPTPN23-dependent ESCRT machinery functions as a cell death checkpoint in restraining multiple cell death pathways
In our study, a CRISPR screen of acute myeloid leukemia cells identifies protein tyrosine phosphatase non-receptor type 23 (PTPN23) as essential for survival. Loss of PTPN23 activates nuclear factor-kappa B, apoptotic, necroptotic, and pyroptotic pathways by causing the accumulation of death recepto...
ORGANISM(S): Homo Sapiens 
PXD056836 |
ProteomicsTMEM16K is an interorganelle regulator of endosomal sorting.
Using proximity biotinylation proteomics based on TMEM16K/Ano10 (an endoplasmic reticulum lipid scramblase causative for spinocerebellar ataxia) BioID chimeras, we identify endosomal transport as a major functional cluster of interacting proteins.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2020-05-30 | PXD018990 | Pride
Bioid Endosomal sorting Tmem16k 
GenomicsSorting nexin 10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting
Sorting nexin 10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting
PRJNA915602 | ENA
ProteomicsVacuolar protein sorting-associated protein 1 (Vps1) has membrane constricting and severing abilities required for endosomal protein trafficking
Pathways that traffic proteins or cargo across organelles are fundamental to maintaining organelle identity and function. These pathways are largely conserved from yeast to humans. The retromer pathway traffics cargo from endosomes to the trans Golgi network (TGN). Defects in this pathway are linked...
ORGANISM(S): Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
2026-09-14 | PXD077915 | Pride
Lipids  membrane templates  membrane fission  fluorescence image analysis  endosome  vacuole  protein sorting  proteomics 
TranscriptomicsSorting nexin 10 sustains platelet-derived growth factor receptor signaling in glioblastoma stem cells via endosomal protein sorting
Glioblastoma is the most malignant primary brain tumor for which the prognosis is still dismal despite aggressive surgical, medical, and radiation therapies. Glioblastoma stem cells (GSCs) promote therapeutic resistance and cellular heterogeneity due to their self-renewal properties and capacity for...
ORGANISM(S): Homo sapiens 
2023-03-31 | GSE221714 | GEO
ProteomicsEndosomal sorting regulates PD-L1 trafficking and enhances immunotherapy efficacy
Immune-checkpoint inhibition affecting the PD-1/PD-L1 pathway is a robust clinical approach to treat cancer. Unfortunately, antibody-binding-caused PD-L1 internalization and recycling can lead to resistance and reduced clinical efficacy. Inhibiting lysosome-mediated PD-L1 degradation is necessary to...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD061780 | Pride
Immune checkpoint inhibitor Pgk1 Endosomal sorting Tm9sf2 Ceramide Pd-l1 Immunotherapy 
ProteomicsPhosphorylation of SNX17 impedes activation of Retriever-mediated sorting
Sorting nexin 17 (SNX17) functions as cargo receptor on endosomal membranes that enables the recycling of numerous membrane cargo proteins by binding to the Retriever complex. Yet, little is known how SNX17 activity or its membrane recruitment is regulated. Here, we report that phosphorylation of SN...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2025-06-30 | PXD061808 | Pride
Endosome Intracellular trafficking Sorting nexin Retriever Phosphorylation Integrin Phox domain 
UnknownTMEM16K is an interorganelle regulator of endosomal sorting.
Not available
S-EPMC7335067 | biostudies-literature
Sort   by:  
 Page size