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MetabolomicsBased on the Metabolomic Approach the Energy Metabolism Responses of Oriental River Prawn Macrobrachium nipponense Hepatopancreas to Acute Hypoxia and Reoxygenation
Hypoxia represents a major physiological challenge for prawns and is a problem in aquaculture. Therefore, an understanding of the metabolic response mechanism of economically important prawn species to hypoxia and re-oxygenation is essential. However, little is known about the intrinsic mechanisms b...
2021-05-17 | MTBLS584 | MetaboLights
MetabolomicsMultiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease
We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were foun...
2025-04-25 | MTBLS4332 | MetaboLights
MetabolomicsLactate-driven lysine lactylation mediates high-level colistin resistance in Salmonella
Intracellular pathogens are particularly refractory to antibiotic eradication, leading to persistent and relapsing infections. However, how intracellular metabolic microenvironments shape antibiotic resistance phenotypes remains poorly understood. Here we delineate a metabolic-regulatory axis wherei...
2026-06-17 | MTBLS14781 | MetaboLights
MetabolomicsSingle-cell and bulk level metabolomic study of the glycolysis inhibition by 2-deoxy-D-glucose in Saccharomyces cerevisiae
Single-cell level measurements are necessary to characterize the intrinsic biological variability in a population of cells. In a study of the metabolic response of a clonal Saccharomyces cerevisiae population challenged by the glycolytic inhibitor 2-deoxy-D-glucose (2-DG), this variability is shown ...
2013-05-22 | MTBLS29 | MetaboLights
MetabolomicsOmics-guided global rewiring of yeast metabolism enables high-level production of β-lactoglobulin
This project contains untargeted metabolomic data generated to investigate the metabolic responses of Komagataella phaffii during methanol-free recombinant beta-lactoglobulin production. The study included the bovine beta-lactoglobulin-producing strain B08 and the feline beta-lactoglobulin-producing...
2026-06-05 | MTBLS14680 | MetaboLights
MetabolomicsDelayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle

Exercise is fundamental to healthy aging, yet the degree to which it mitigates age-related molecular changes and how varying physical fitness levels influence the molecular response to exercise with age remain unclear. To address this, we performed transcriptomics, lipidomics, and metabolomics on...

2026-04-09 | MTBLS12824 | MetaboLights
MetabolomicsMetabolic dysregulation in vitamin E and carnitine shuttle energy mechanisms associate with human frailty
Global ageing poses a substantial economic burden on health and social care costs. Enabling a greater proportion of older people to stay healthy for longer is key to the future sustainability of health, social and economic policy. Frailty and associated decrease in resilience plays a central role in...
2019-09-06 | MTBLS598 | MetaboLights
MetabolomicsHigh-level de novo synthesis of medical plant derived flavonoid glycosides
Pichia pastoris is a widely used eukaryotic host for recombinant protein expression in biopharmaceutical and biomanufacturing, offering advantages such as broad carbon source utilization, high cell density, a mature fermentation process, and genomic stability. Recent advances in genetic editing and ...
2025-08-22 | MTBLS12177 | MetaboLights
MetabolomicsIsoquercitrin alleviates subchronic high-altitude hypoxia-induced myocardial injury by regulating mitochondrial energy metabolism and maintaining immune–inflammatory homeostasis
High-altitude hypoxia induces myocardial metabolic disorders, structural remodeling, and functional impairment, which threaten the health of highland populations. The interventional effects and molecular mechanisms of isoquercitrin (IQ), a natural flavonoid with cardiovascular protective activity, a...
2026-07-29 | MTBLS15192 | MetaboLights
MetabolomicsBacillus siamensis to restore the compromised amino acid and energy metabolism of Mesorhizobium metallidurans under saline alkali stress

Bacillus siamensis to restore the compromised amino acid and energy metabolism of Mesorhizobium metallidurans under saline alkali stress

2025-07-16 | MTBLS12729 | MetaboLights
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