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UnknownDetecting Germline PTEN Mutations Among At-Risk Patients With Cancer: An Age- and Sex-Specific Cost-Effectiveness Analysis.
Not available
S-EPMC4525048 | biostudies-literature
TranscriptomicsTranscription profiling of human benign and malignant thyroid follicular neoplasi
Differentiation between Follicular Thyroid Carcinoma and Follicular Thyroid Adenoma based on their genetic signature
ORGANISM(S): Homo sapiens 
2005-01-01 | E-MEXP-97 | biostudies-arrayexpress
Proteomics(Phospho)Proteomic Characterization of Ptenm3m4 Cortex
PTEN has a strong Mendelian association with autism spectrum disorder (ASD), representing a special case in autism’s complex genetic architecture. Animal modeling for constitutional Pten mutation creates an opportunity to study how disruption of Pten affects neurobiology and glean potential insight ...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025351 | Pride
Lc-msms Autism Mouse Pten 
TranscriptomicsProstatic Stromal Cell Gene Expression
We generated prostatic stromal microarray expression data for functional validation of our LOH/AI hot-/cold-spots in stroma. Stromal cells from normal peripheral zone tissue and from tumors are grown in culture, and were analyed on gene expression platform. Stromal cells cultured from normal periphe...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-34312 | biostudies-arrayexpress
TranscriptomicsSpecific kinesin expression profiles associated with taxane resistance in breast cancer
Purpose: Breast cancer is a genetically heterogenous disease with subtypes differing in prognosis and chemosensitivity. The basal-like breast cancer (BLBC) molecular subtype is associated with poorer outcomes, but is more responsive to taxane-based chemotherapy. We evaluated the role of kinesins, mo...
ORGANISM(S): Homo sapiens 
2012-12-01 | E-GEOD-22796 | biostudies-arrayexpress
TranscriptomicsGenome-wide gene expression profile analysis in pulmonary sarcoidosis
We hypothesized that tissue genome-wide gene expression analysis, coupled with gene network analyses of differentially expressed genes, would provide novel insights into the pathogenesis of pulmonary sarcoidosis. Keywords: Disease state analysis Genome-wide gene expression profiles were compared in...
ORGANISM(S): Homo sapiens 
2009-06-11 | E-GEOD-16538 | biostudies-arrayexpress
TranscriptomicsRNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
A1AT deficiency is an autosomal not recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant retain polymerised protein in the endoplasmic reticulum of hepatocytes, predisposing them to liver disease. This study primarily aimed to uncover the molecular mechanisms t...
ORGANISM(S): Homo sapiens 
2018-06-26 | E-MTAB-6781 | biostudies-arrayexpress
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