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TranscriptomicsPlasmodium falciparum treated with cyclohexylamine
Transcriptional profiling of P. falciparum cultures treated with cyclohexylamine over time (18, 25 and 30 hours post invasion) A control experiment was also set up in which P. falciparum was not treated with cyclohexylamine, and samples were taken at 18, 25 and 30 h post invasion). Background Plasm...
ORGANISM(S): Plasmodium falciparum 
2010-04-19 | E-GEOD-18075 | biostudies-arrayexpress
ProteomicsGLP-1R/GCGR dual agonism dissipates hepatic steatosis to restore insulin sensitivity and rescue pancreatic β-cell function in obese mice
Early drivers of Type 2 diabetes mellitus (T2D) include ectopic fat accumulation, especially in the liver, that significantly impairs insulin sensitivity. In a T2D setting, GLP-1R/GCGR dual agonists have been shown to reduce glycaemia, body weight and hepatic steatosis. We utilized cotadutide, a wel...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-28 | PXD057744 | Pride
Hepatic steatosis Mass spectrometry T2d Insulin signaling Phosphorylation Liver 
ProteomicsA mass spectrometry-based approach for the identification of Kpnβ1 binding partners in cancer cells
Karyopherin beta 1 (Kpnβ1) is the principal nuclear importer of cargo proteins and plays a role in many cellular processes. Its expression is upregulated in cancer and essential for cancer cell viability, thus the identification of its binding partners might help in the discovery of anti-cancer ther...
ORGANISM(S): Homo sapiens (Human) 
2022-11-03 | PXD034805 | Pride
Cancer Kpnb1 
GenomicsNeuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state
We report the application of single molecule-based sequencing technology for high-throughput genom-wide mapping of MeCP2 binding and DNA methylation in mouse brain and cerebellum respectively. We find a good correlation between MeCP2 occupancy and methyl-CpG density and depletion of MeCP2 binding at...
ORGANISM(S): Mus musculus 
2010-03-04 | E-GEOD-19786 | biostudies-arrayexpress
GenomicsCell Type-Specific DNA Methylation at Intragenic CpG Islands in the Immune System (MAP-Seq and ChIP-Seq data)
Human and mouse genomes contain a similar number of CpG islands (CGIs), which are discrete CpG-rich DNA sequences associated with transcription start sites. In both species, about 50% of all CGIs are remote from annotated promoters, but nevertheless often have promoter-like features. To document the...
ORGANISM(S): Mus musculus 
2011-05-23 | E-GEOD-25688 | biostudies-arrayexpress
GenomicsComprehensive analysis of orphan CpG islands identifes novel promoters with conserved DNA methylation dynamics
We report the application of single molecule-based sequencing technology in combination with CXXC affinity purifcation (CAP-seq), MBD affinity purification (MAP-seq) and chromatin immunoprecipitation (ChIP-seq) to generate reciprocal methylation and chromatin modifcation maps in human and mouse. We ...
ORGANISM(S): Mus musculus 
2010-10-04 | E-GEOD-21442 | biostudies-arrayexpress
GenomicsGenome-wide maps of CFP1, RNA Polymerase II and H3K4me3 in mouse brain.
We report the application of single molecule-based sequencing technology for high-throughput mapping of CFP1, RNA polymerase II and H3K4me3 in mouse brain. By obtaining sequence from chromatin immunoprecipitated DNA, we generated genome-wide binding / chromatin-state maps for mouse brain. We find a ...
ORGANISM(S): Mus musculus 
2010-04-15 | E-GEOD-18578 | biostudies-arrayexpress
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