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ProteomicsDesumoylation of the RNA polymerase III lies at the core of the Sumo-Stress Response
Posttranslational modification by the small ubiquitin-like modifier Sumo regulates many cellular processes including the adaptive response to various types of stress, which has been referred to as Sumo Stress Response (SSR). However, it remains unclear whether the SSR involves a common set of core p...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-11-01 | PXD013884 | Pride
Transfer rna (trna) Stress response Saccharomyces cerevisiae Small ubiquitin‐like modifier (sumo) Transcription regulation Rna polymerase iii 
ProteomicsCdk1 Gates Cell Cycle-Dependent tRNA Synthesis by Regulating RNA Polymerase III Activity
tRNA genes are transcribed by RNA polymerase III (RNAPIII). During recent years it has become clear that RNAPIII activity is strictly regulated by the cell in response to environmental cues and the homeostatic status of the cell. However, the molecular mechanisms that control RNAPIII activity to reg...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2018-10-19 | PXD011084 | Pride
Transcription Cdk1 Trna Cell cycle 
ProteomicsTORC1 shapes the SUMO proteome to control RNA Polymerase III activity
Loss of nutrient supply elicits alterations of the SUMO proteome and sumoylation is crucial to various cellular processes including transcription. However, the physiological significance of sumoylation of transcriptional regulators is unclear. To begin clarifying this, we mapped the SUMO proteome un...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2017-01-21 | PXD005142 | Pride
Transcription Sumoylation Rna polymerase Saccharomyces cerevisiae Chip-seq Lc-ms/ms 
ProteomicsA cell competition-based drug screen identifies a novel compound that induces dual c-Myc degradation and p53 activation
BCR-Abl is a driver oncogene that causes chronic myeloid leukemia and a subset of acute lymphoid leukemias. Although tyrosine kinase inhibitors provide an effective treatment for these diseases, they generally do not kill leukemic stem cells. Leukemic stem cells are cancer-initiating cells that comp...
ORGANISM(S): Mus musculus (Mouse) 
2020-12-07 | PXD018812 | Pride
Leukemia C-myc Drug screening Anticancer drug Abl tyrosine kinase Phosphoproteomics Mrna P53 
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