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ProteomicsPeptidomics of enteroendocrine cells and characterisation of potential effects of a novel preprogastrin derived-peptide on glucose tolerance in lean mice
To analyse the peptidomics of mouse enteroendocrine cells (EECs) and human gastrointestinal (GI) tissue and identify novel gut derived peptides. High resolution nano-flow liquid chromatography mass spectrometry (LCMS) was performed on (i) flow-cytometry purified NeuroD1 positive cells from mouse an...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-29 | PXD024050 | Pride
Enteroendocrine cells  peptidomics  mass spectrometry  prohormones  granins  progastrin 
TranscriptomicsRNA-Seq analysis of mouse small intestine enteroendocrine cells
We generated knock-in mice expressing GFP under the control of the endogenous GIP (Glucose-dependent Insulinotropic Polypeptide) promoter that enable the isolation of a purified population of small intestine K cells. Using RNA-Seq, we comprehensively characterized the transcriptomes of GIP-GFP cells...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-61250 | biostudies-arrayexpress
ProteomicsHigh Resolution mRNA and Secretome Atlas of Human Enteroendocrine Cells
Enteroendocrine cells (EECs) sense intestinal content and release hormones to regulate gastrointestinal activity and systemic metabolism and food intake. Little is known about the molecular make-up of human EEC subtypes and the regulated secretion of individual hormones. Here we describe an organoid...
ORGANISM(S): Homo sapiens (Human) 
2020-05-15 | PXD017468 | Pride
Organoids Peptide hormones Eec Secretome 
UnknownA Systematic Analysis of Drosophila Regulatory Peptide Expression in Enteroendocrine Cells.
Not available
S-EPMC4844944 | biostudies-literature
TranscriptomicsDistinct Cellular Origins for Serotonin-Expressing and Enterochromaffin-like Cells in the Gastric Corpus
The alimentary tract contains a diffuse endocrine system comprising enteroendocrine cells that secrete peptides or biogenic amines to regulate digestion, insulin secretion, food intake, and energy homeostasis. Lineage analysis in the stomach revealed that a significant fraction of endocrine cells in...
ORGANISM(S): Mus musculus 
2013-12-12 | E-GEOD-53214 | biostudies-arrayexpress
GenomicsMouse duodenal enteroendocrine transcriptome
Mouse duodenal enteroendocrine transcriptome
PRJNA473085 | ENA
GenomicsHuman enteroendocrine cell transcriptomic profiling
Human enteroendocrine cell transcriptomic profiling
PRJNA472863 | ENA
ProteomicsAn integral atlas of hormone peptides of human EECs and their dedicated proteases
Enteroendocrine cells (EECs) secrete hormones in response to ingested nutrients to control physiological processes such as appetite and insulin release. EEC hormones are synthesized as large pre-proteins that undergo proteolytic processing through peptidases to generate bioactive peptides. Due to th...
ORGANISM(S): Homo sapiens (Human) 
2022-11-26 | PXD033369 | Pride
Peptidomics Lc-msms Proteolytic processing Hormones Enteroendocrine cells 
GenomicsSingle cell transcriptomic profiling of large intestinal enteroendocrine cells in mice
Single cell transcriptomic profiling of large intestinal enteroendocrine cells in mice
PRJNA565952 | ENA
GenomicsShort-term depletion of acetylcholine synthesis in Drosophila enteroendocrine cells
Short-term depletion of acetylcholine synthesis in Drosophila enteroendocrine cells
PRJNA988541 | ENA
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