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ProteomicsHuman breast milk enhances intestinal mucosal barrier function and innate immunity in a pediatric human enteroid model
Breastfeeding has been associated with long lasting health benefits. Nutrients and bioactive components of human breast milk promote cell growth, immune development, and shield the infant gut from insults and microbial threats. The molecular and cellular events involved in these processes are ill de...
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025966 | Pride
Pediatric Enteroids Breatsmilk 
ProteomicsAn open-format enteroid culture system for interrogation of interactions between Toxoplasma gondii and the intestinal epithelium
When transmitted through the oral route, Toxoplasma gondii first interacts with its host at the small intestinal epithelium. This interaction is crucial to controlling initial invasion and replication, as well as shaping the quality of the systemic immune response. It is therefore an attractive targ...
ORGANISM(S): Toxoplasma gondii Mus musculus (Mouse) 
2019-11-12 | PXD013306 | Pride
Host-pathogen interaction Toxoplasma gondii 3d enteroids 
ProteomicsProteomic profiling of enteroid cultures skewed towards development of specific epithelial lineages
Recently, three-dimensional small intestinal organoids (enteroids) have been developed from cultures of intestinal stem cells which differentiate in vitro to generate all the differentiated epithelial cell types associated with the intestine and mimic the structural properties of the intestine obser...
ORGANISM(S): Mus musculus (Mouse) 
2019-01-11 | PXD005006 | Pride
Differentiation  mass spectrometry  gastrointestinal system  stem cells 
GenomicsTranscriptional response of human duodenal enteroid monolayers to norovirus infection
Transcriptional response of human duodenal enteroid monolayers to norovirus infection
PRJNA759636 | ENA
GenomicsHuman Enteroid Monolayers: A Novel, Functionally-Stable Model for Investigating Oral Drug Disposition
Human Enteroid Monolayers: A Novel, Functionally-Stable Model for Investigating Oral Drug Disposition
PRJNA1066394 | ENA
TranscriptomicsscRNA-seq of human fetal duodenal enteroids grown in EGF and/or NRG1
The purpose of this study was to interrogate the role of EGF-family ligands, in particular Epidermal Growth Factor (EGF) and Neuregulin 1 (NRG1), as human intestinal stem cell niche factors. An established duodenal enteroid line derived from a 20.2 week post conception biological specimen was expose...
ORGANISM(S): Homo sapiens 
2020-12-10 | E-MTAB-9720 | biostudies-arrayexpress
TranscriptomicsHuman Enteroid Monolayers: A Novel, Functionally-Stable Model for Investigating Oral Drug Disposition
To further the development of an in vitro model that can more faithfully recapitulate drug disposition of orally administered drugs, we investigated the utility of human enteroid monolayers to simultaneously assess intestinal drug absorption and first-pass metabolism processes. We cultured human ent...
ORGANISM(S): Homo sapiens 
2025-01-17 | GSE253641 | GEO
UnknownIn Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis.
Not available
S-EPMC9682421 | biostudies-literature
UnknownControlling Epithelial Polarity: A Human Enteroid Model for Host-Pathogen Interactions.
Not available
S-EPMC6391775 | biostudies-literature
TranscriptomicsEpithelial maturation of human intestinal organoids from pluripotency entirely in vitro
In vitro human pluripotent stem cell derived intestinal organoids (HIOs) are immature and lack for diverse differentiated secretory cell types. We would like to test the hypothesis whether addition of a mesenchyme secreting ligand which is depleted in canonical organoid culture media could increase ...
ORGANISM(S): Homo sapiens 
2022-12-31 | E-MTAB-10876 | biostudies-arrayexpress
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