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TranscriptomicsTranscription profiling of rat young and aged entorhinal cortex and hippocampus one month after entorhinal administration of BDNF lentivirus
Patterns of gene expression in the aged entorhinal cortex and hippocampus were examined one month after entorhinal administration of BDNF lentivirus. Whole-genome patterns of expression were examined using Affymetrix arrays four weeks after entorhinal injection of lentiviral-BDNF or GFP injection co...
ORGANISM(S): Rattus norvegicus 
2009-01-31 | E-GEOD-14505 | biostudies-arrayexpress
ProteomicsProteomic analyses of human entorhinal cortex in Alzheimer's disease
This project aims to characterize the proteomic profile of human entorhinal cortex regarding Alzheimer's disease by SWATH-MS technique.
ORGANISM(S): Homo sapiens (Human) 
2023-06-20 | PXD029359 | Pride
Proteomics Alzheimer Entorhinal 
TranscriptomicsMolecular profiles of cognitive aging
Gene expression was measured from the dentate gyrus and entorhinal cortex harvested from human postmortem samples. We harvested the dentate gyrus DG from healthy human brains ranging from 33 to 88 years of age. Additionally, from each brain we harvested the entorhinal cortex (EC) as a within-brain c...
ORGANISM(S): Homo sapiens 
2013-04-19 | E-GEOD-46193 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse APP transgenic mouse model of Alzheimers disease treated with BDNF
We examined transgenic (TG) mice expressing human APP695 bearing the double Swedish (671KM>NL) and Indiana (717V>F) amyloid precursor protein (APP) mutations. Lentiviral vectors constitutively expressing BDNF-GFP under control of the CMV/ß-actin hybrid promoter or GFP alone were injected into the e...
ORGANISM(S): Mus musculus 
2009-02-01 | E-GEOD-14499 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human entorhinal cortex cells from suicide patients with major depression.
RNAs were extracted from entorhinal cortex of human suicide patients with major depression and matched control subjects. The transcription profile was investigated by Agilent microarray platform and quantitative real-time PCR to reveal alterations in neuronal functions in this brain region.
ORGANISM(S): Homo sapiens 
2010-12-31 | E-MEXP-2607 | biostudies-arrayexpress
TranscriptomicsExpression data from left versus right mouse entorhinal cortex (EC).
The entorhinal cortex of the mouse seems to be sensitive to molecular mechanisms that have been linked to the pathology of Alzheimer's disease. In this microarray study we are interested in comparing the expression profile of the left versus the right EC of the mouse, in order to understand if there...
ORGANISM(S): Mus musculus 
2013-07-30 | E-GEOD-49311 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lower and upper entorhinal cortex layers gene expression
Specific vulnerability of neurons in the human entorhinal cortex has been associated with the onset of disease. Gene expression is analyzed to define the molecular characteristic of those neurons. Experiment Overall Design: Human tissue collection and dissection. Brain samples were collected from ...
ORGANISM(S): Homo sapiens 
2009-10-30 | E-GEOD-18696 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human neurons with and without neurofibriallary tangles from Alzheimer's patients
Alzheimer's Disease (AD) is a devastating neurodegenerative disorder affecting approximately 4 million people in the U.S. alone. AD is characterized by the presence of senile plaques and neurofibrillary tangles in cortical regions of the brain. These pathological markers are thought to be responsi...
ORGANISM(S): Homo sapiens 
2009-09-05 | E-GEOD-4757 | biostudies-arrayexpress
ProteomicsProteomic analysis of the entorhinal cortex and CA1 subfields of the hippocampus of macaques injected with tau seeds from Alzheimer’s brain
The "prion-like" features of Alzheimer’s disease (AD) tauopathy and its relationship with amyloid β (Aβ) has never been experimentally studied in primates phylogenetically close to humans. We injected 17 macaques in the entorhinal cortex with nanograms of tau proteopathic seeds purified from AD brai...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2024-01-02 | PXD040522 | Pride
Tau Macaque Alzheimer Proteome 
UnknownMinute-scale oscillatory sequences in medial entorhinal cortex.
Not available
S-EPMC10781645 | biostudies-literature
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