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MetabolomicsResponse Mechanisms of Hepatopancreatic Metabolism and Gut Microbiota in Chinese Mitten Crab (Eriocheir sinensis) Under Chronic High-pH Stress

This study subjected Eriocheir sinensis to chronic high-pH stress (control: pH=8; experimental groups: pH=9 and pH=10) and integrated hepatopancreas transcriptomic/metabolomic analyses with intestinal microbiota 16S rRNA sequencing to explore its adaptive mechanisms. The results revealed distinct...

2026-07-04 | MTBLS13708 | MetaboLights
TranscriptomicsLactobacillus plantarum IMDO 130201, a wheat sourdough isolate, adapts to growth in wheat sourdough simulation medium at different pH values through differential gene expression
Sourdough is a very competitive and challenging environment for microorganisms. Usually, a stable microbiota composed of lactic acid bacteria (LAB) and yeasts comes to dominate this ecosystem. Although rich in carbohydrates, thus providing an ideal environment to grow, the low pH presents a particul...
ORGANISM(S): Lactobacillus plantarum 
2011-07-31 | E-GEOD-23945 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human oesophageal cells stimulated with a low pH environment
Differential gene expression analysis of oesophageal cells stimulated with a low pH environment. Study designed to identify pathways involved in progression of gastro-oesophageal reflux disease through Barrett's oesophagus to adenocarcinoma. Identified many subsets of genes with involvement in patho...
ORGANISM(S): Homo sapiens 
2007-08-25 | E-GEOD-2144 | biostudies-arrayexpress
TranscriptomicsEffect of pH on Cadmium Toxicity in Escherichia coli
Metals at high concentrations can exert toxic effects on microorganisms. It has been widely reported that lowering environmental pH reduces effects of cadmium toxicity in bacteria. Understanding the effects of pH-mediated cadmium toxicity on bacteria would be useful for minimizing cadmium toxicity...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2008-08-21 | E-GEOD-12373 | biostudies-arrayexpress
TranscriptomicsThe pH-sensing receptor OGR1 improves barrier function of CaCo-2 cells and inhibits migration in an acidic environment
OGR1 is a pH-sensing G-protein coupled receptor involved in intestinal homeostasis and inflammation Proton activation of OGR1 increases barrier function in Caco2 cells Microarray profiling was performed on OGR1 stable overexpressing Caco-2 cells during acidic pH shift
ORGANISM(S): Homo sapiens 
2015-08-13 | E-GEOD-60294 | biostudies-arrayexpress
TranscriptomicsSevere alkaline pH stress induces a glucose starvation-related transcriptional response in S. cerevisiae
Alkaline pH stress invokes in S. cerevisiae a potent and fast transcriptional response that includes many genes repressed by glucose. Certain mutants in the glucose-sensing and response pathways, such as those lacking the Snf1 kinase, are sensitive to alkalinization. We show that addition of glucose...
ORGANISM(S): Saccharomyces cerevisiae 
2012-03-02 | E-GEOD-25697 | biostudies-arrayexpress
TranscriptomicsIdentification of HP0244 regulon at different pH conditions
Transcriptional profiling of Helicobacter pylori comparing 26695 wild-type strain and a HP0244-deficient mutant 26695/∆HP0244::km treated at three different pH conditions (pH 7.4, pH 4.5 without urea, or pH 2.5 with 30 mM urea) for 30 min to define the HP0244 acid-responsive regulon Keywords: Gen...
ORGANISM(S): Helicobacter pylori 
2010-05-05 | E-GEOD-12900 | biostudies-arrayexpress
ProteomicsProtein Phosphorylation Orchestrates Acclimations of Arabidopsis Plants to Environmental pH
In lieu of strategies to escape unfavorable conditions, plants have evolved mechanisms to cope with and adapt to changes in their environment. Environment pH (pHe) is a key parameter that dictates a surfeit of conditions of critical importance for plant survival and fitness. Besides responses to alt...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2023-09-18 | PXD045226 | Pride
Arabidopsis Protein phosphorylation Environment ph 
TranscriptomicsGenome wide transcriptional analysis of P. aeruginosa PAO1 response to pH at 25 mM phosphate background
During extreme physiological stress, the intestinal tract can be transformed into a harsh environment characterized by regio- spatial alterations in oxygen, pH, and phosphate concentration. When the human intestine is exposed to extreme medical interventions, the normal flora becomes replaced by pat...
ORGANISM(S): Pseudomonas aeruginosa PAO1 
2011-10-05 | E-GEOD-29789 | biostudies-arrayexpress
ModelsStephanou2019 - pH as a potential therapeutic target to improve temozolomide antitumor efficacy
Abstract: Despite intensive treatments including temozolomide (TMZ) administration, glioblastoma patient prognosis remains dismal and innovative therapeutic strategies are urgently needed. A systems pharmacology approach was undertaken to investigate TMZ pharmacokinetics‐pharmacodynamics (PK‐PD) inc...
2019-09-30 | MODEL1909300003 | BioModels
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