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MetabolomicsEffect of Zanthoxylum bungeanum essential oil on rumen enzyme activity, microbiome, and metabolites in lambs

Antibiotics were once used in animal production to improve productivity and resistance to pathogenic microbiota. However, due to its negative effects, the search for a new class of substances that can replace its efficacy has become one of the urgent problems to be solved. Plant essential oils (E...

2022-09-13 | MTBLS3683 | MetaboLights
TranscriptomicsExperimental analysis of oligonucleotide microarray design criteria to detect deletions by CGH
BACKGROUND: Microarray comparative genomic hybridization (CGH) is currently one of the most powerful techniques to measure DNA copy number in large genomes. In humans, microarray CGH is widely used to assess copy number variants in healthy individuals and copy number aberrations associated with var...
ORGANISM(S): Homo sapiens 
2008-07-26 | E-GEOD-12208 | biostudies-arrayexpress
TranscriptomicsExperimental validation of HiSpOD probe design with complex background mRNA or 3 known antiense RNA and expression analysis on a contaminated groundwater sample
HiSpOD is a new efficient functional microarrays probe design algorithm especially dedicated for the microbial ecology and environmental studies. It was used to design 3392 probes targeting 21 genes involved in chlorinated solvent biodegradation pathways and synthesized on a nimblegen microarray. In...
ORGANISM(S): uncultured organism 
2011-04-13 | E-GEOD-21492 | biostudies-arrayexpress
ProteomicsComputational design of Matrix Metalloprotenaise-9 (MMP-9) resistant to auto-cleavage
Matrix metalloproteinase-9 (MMP-9) is an endopeptidase that remodels the extracellular matrix and has been implicated as a major driver in cancer metastasis. Hence, there is a high demand for MMP-9 inhibitors for therapeutic purposes. For such drug design efforts, large amounts of MMP-9 are required...
ORGANISM(S): Escherichia coli 
2023-10-24 | PXD041767 | Pride
Mmp-9 Auto-cleavage Protein engineering Auto-degradation Enzyme engineering Matrix metalloproteases 
UnknownDe novo enzyme design using Rosetta3.
Not available
S-EPMC3095599 | biostudies-literature
UnknownLibGENiE - A bioinformatic pipeline for the design of information-enriched enzyme libraries.
Not available
S-EPMC10510078 | biostudies-literature
UnknownAsiteDesign: a Semirational Algorithm for an Automated Enzyme Design.
Not available
S-EPMC10068746 | biostudies-literature
ProteomicsThe Glycosylation Design Space for Recombinant Lysosomal Replacement Enzymes Produced in CHO Cells
Lysosomal storage diseases are rare life-threatening disorders caused by deficiency of a lysosomal enzyme, and delivery of a recombinant replacement enzyme is the primary therapy for several of these diseases. The structures of N-glycans on recombinant replacement enzymes are important for their the...
ORGANISM(S): Homo sapiens (Human) Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) 
2019-05-31 | PXD013140 | Pride
N-glycoproteomics Enzyme replacement therapy Glycoengineering 
TranscriptomicsAnalysis and design of RNA sequencing experiments for identifying mRNA isoform regulation
Through alternative splicing, most human genes express multiple isoforms that may have distinct or even antagonistic functions. To infer isoform regulation based on data from high-throughput sequencing of cDNA fragments (RNA-Seq), we have developed MISO, a computational model that estimates the expr...
ORGANISM(S): Homo sapiens 
2010-11-07 | E-GEOD-23694 | biostudies-arrayexpress
ProteomicsRational Design of High Affinity Peptides Validates Histone Chaperone ASF1 as a New Epigenetic Target in Cancer
Starting from the structure of the human ASF1-histone complex, we developed a rational design strategy combining epitope tethering and optimization of interface contacts to identify a potent peptide inhibitor with a dissociation constant of 3 nM. LC-MS/MS was used to identify in vivo targets of the ...
ORGANISM(S): Homo sapiens (Human) 
2019-09-25 | PXD013279 | Pride
Peptide design Inhibitory peptides Histone chaperone 
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