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MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
MetabolomicsSerine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism and mTORC1 signaling

Cells use glycolytic intermediates for anabolism e.g., via the serine synthesis and pentose phosphate pathways. However, we still understand poorly how these metabolic pathways contribute to skeletal muscle cell biomass generation. The first aim of this study was therefore to identify enzymes tha...

2025-03-21 | MTBLS8854 | MetaboLights
TranscriptomicsExpression data from LPS-stimulated RAW 264.7 mouse macrophages treated with Hypericum perforatum fraction and bioactive constituents
Hypericum perforatum extracts have been used as dietary supplements to treat conditions including mild-moderate depression and inflammation. A group of four bioactive constituents were identified from an active fraction of the extract. In order to identify the mechanism for the potential anti-inflam...
ORGANISM(S): Mus musculus 
2010-05-28 | E-GEOD-21841 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of the human Lineage– cells derived from the adipose stromal vascular fraction across depots
We used single-cell RNA-seq to characterize the heterogeneity of the human Lin- stromal vascular fraction across five adipose depots. We mollecularly assessed Lin- SVF cells from subcutaneous, omentum, mesocolic, and perirenal fat depots, as well as gallbladder-associated fat using 10x Genomics.
ORGANISM(S): Homo sapiens 
2023-09-30 | E-MTAB-12893 | biostudies-arrayexpress
ProteomicsLC-MS/MS Analysis of the Active Fraction DEAE-2 Purified from the Artemisia annua Crude Enzyme
The crude enzyme extract from Artemisia annua was subjected to catalytic activity-guided purification and fractionation, yielding the active fraction DEAE-2, which demonstrated the biological function of catalyzing the interconversion between artemisinic acid and dihydroartemisinic acid. Proteomic i...
ORGANISM(S): Artemisia annua (Sweet wormwood) 
2025-04-14 | PXD062563 | Pride
Active component deae-2 Artemisia annua Lc-ms/ms 
TranscriptomicsTranscription factor AbVf19 induces hydrolytic enzyme genes during pathogenesis in Alternaria brassicicola
Alternaria brassicicola is a successful saprophyte and necrotrophic pathogen with a broad host range. It produces secondary metabolites that marginally affect virulence, in contrast to many A. alternata strains that produce secondary metabolites as host-specific pathogenicity factors. Cell wall-de...
ORGANISM(S): Brassica oleracea 
2012-05-03 | E-GEOD-33148 | biostudies-arrayexpress
TranscriptomicsGene expression in canine adipose stromal vascular fraction
Microarray studies were performed to identify expression patterns by cryopreserved adipose stromal vascular fraction (SVF) preparations that were prepared by three different veterinary stem cell companies from the same source of canine adipose tissue. [Samples 1 - 3] Three equal samples of approxima...
ORGANISM(S): Canis lupus familiaris 
2014-03-05 | E-GEOD-55351 | biostudies-arrayexpress
TranscriptomicsRNAi knock down of four Argonaute paralogs (AGO1, AGO2, PIWI and Aubergine) and the microRNA-processing enzyme Drosha in Drosophila
RNA silencing pathways are conserved gene regulation mechanisms that lead to degradation, translational repression or transcriptional silencing of target-transcripts selected based on complementarity with small RNA molecules. The fraction of the genome regulated by these pathways has not been establ...
ORGANISM(S): Drosophila melanogaster 
2006-11-20 | E-MEXP-295 | biostudies-arrayexpress
TranscriptomicsSingle nuclei sequencing of human and Mice HFrEF data (Heart Failure with reduced ejection fraction)
Here we provide snRNA-seq datasets from heart failure patients with reduced ejection fraction and snRNA-SEQ of the corresponding LAD mouse model (permanent ligation of the left anterior descending artery)
ORGANISM(S): Mus musculus 
2023-08-20 | E-MTAB-13264 | biostudies-arrayexpress
ProteomicsAnalysis of the nuclear proteome fraction of rAAV2-plasmid transfected HEK-293 cells during AAV production
In this comparative proteomic analysis, we focused on proteins in the nuclear fraction. As the nucleus is the epicenter of DNA uptake, transcription, capsid assembly and packaging. Three HEK-293 cell samples i) not transfected, ii) MOCK plasmid transfected, and iii) triple-transfected with rAAV2-pro...
ORGANISM(S): Homo sapiens (Human) 
2025-07-21 | PXD062079 | Pride
Ms/ms Nuclear fraction Fasp Raav production 
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