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ProteomicsUnmasking functional redundancy of deubiquitylases enables specificity profiling and discovery of novel proteasome substrates
Deubiquitylating enzymes (DUBs) counteract ubiquitylation to control the stability or activity of their substrates. Identifying DUB substrates is challenging and genetic approaches can be thwarted by redundant action of DUBs. Here, we circumvented redundancy by broadly inhibiting DUBs in Xenopus egg...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-09-02 | PXD016164 | Pride
Ubiquitin Tmt Xenopus Degradation Proteasome Dub 
UnknownFunctional redundancy in tRNA dihydrouridylation.
Not available
S-EPMC11162810 | biostudies-literature
ProteomicsProteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity
Deubiquitylating enzymes (DUBs) counteract ubiquitylation to control stability or activity of substrates. Identification of DUB substrates is challenging because multiple DUBs can act on the same substrate, thwarting genetic approaches. Here, we circumvent redundancy by chemically inhibiting multipl...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-09-02 | PXD022762 | Pride
Xenopus Dub Sps-ms3 Ubiquitin 
ProteomicsProteomics of broad deubiquitylase inhibition unmasks redundant enzyme function to reveal substrates and assess enzyme specificity
Deubiquitylating enzymes (DUBs) counteract ubiquitylation to control stability or activity of substrates. Identification of DUB substrates is challenging because multiple DUBs can act on the same substrate, thwarting genetic approaches. Here, we circumvent redundancy by chemically inhibiting multipl...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2021-09-09 | PXD022740 | Pride
Xenopus Dub Sps-ms3 Ubiquitin 
UnknownQuantifying functional redundancy in polysaccharide-degrading prokaryotic communities.
Not available
S-EPMC11218364 | biostudies-literature
ProteomicsEpistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
In malaria parasites, evolution of parasitism has been linked to functional optimisation. Despite this optimisation, most members of a calcium-dependent protein kinase (CDPK) family show genetic redundancy during erythrocytic proliferation. To identify relationships between phospho-signalling pathwa...
ORGANISM(S): Plasmodium berghei ANKA 
2018-09-17 | PXD011096 | Pride
Plasmodium berghei Schizont Cdpk 
ProteomicsRedundancy and Complementarity between ERAP1 and ERAP2 Revealed by their Effects on the Behçet’s Disease-Associated HLA-B*51 Peptidome
The endoplasmic reticulum aminopeptidases ERAP1 and ERAP2 trim peptides to be loaded onto HLA molecules, including the main risk factor for Behçet’s disease HLA-B*51. ERAP1 is also a risk factor among HLA-B*51-positive individuals, whereas no association is known with ERAP2. This study addressed the...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD012348 | Pride
Hla-b*51 Erap1 Behçet’s disease Erap2 Peptidome 
UnknownRedundancy and metabolic function of the glutamine synthetase gene family in poplar.
Not available
S-EPMC4329200 | biostudies-literature
UnknownA kinetic rationale for functional redundancy in fatty acid biosynthesis.
Not available
S-EPMC7519226 | biostudies-literature
TranscriptomicsCHD5, A Brain-Specific Chromatin Remodeling Enzyme, Regulates Expression Of Neuronal Genes.
CHD5 is frequently deleted in neuroblastoma, and appears to be a tumor suppressor gene; however, little is known about the role of CHD5. We found CHD5 mRNA was restricted to brain; by contrast most other remodeling ATPases were broadly expressed. CHD5 protein isolated from mouse brain was associat...
ORGANISM(S): Rattus norvegicus 
2011-09-21 | E-GEOD-27620 | biostudies-arrayexpress
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