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ProteomicsMembranes prime the RapGEF EPAC1 to transduce cAMP signaling
EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling in normal cells and a therapeutic target in cardiac diseases. The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of EPAC1 activation in the cytosol. Her...
ORGANISM(S): Homo sapiens (Human) 
2023-04-07 | PXD040227 | Pride
Hdxms Epac1 
GenomicsPodocyte Epac1 promotes glycolysis and protects against glomerulonephritis
Podocyte Epac1 promotes glycolysis and protects against glomerulonephritis
PRJNA993701 | ENA
ProteomicsEPAC1 knockout mouse effects in platelets and plasma
ABSTRACT FOR BOTH PLASMA AND PLATELET-LYSATE In this article we describe the involvement of exchange factor activated by cAMP 1 (Epac1) in hemostasis and platelet activation. We have used plasma and platelet-lysate from EPAC1 knockout mice and wild-type control mice in label-free proteomics with an ...
ORGANISM(S): Mus musculus (Mouse) 
2017-07-25 | PXD000282 | Pride
Epac1 knockout Platelets Lc-ms Plasma Label-free 
ProteomicsEPAC1 enhances energy expenditure by selectively inducing brown and beige adipose tissue growth
Brown adipose tissue (BAT) is a central thermogenic organ that enhances energy expenditure (EE) and cardiometabolic health. However, regulators that specifically increase the number of thermogenic adipocytes are still an unmet need. Here, we show by phosphoproteomics that cAMP activates distinct sig...
ORGANISM(S): Mus musculus (Mouse) 
2023-11-11 | PXD046709 | Pride
Brown adipocyte Epac 
GenomicsEndothelial Epac1 facilitates YAP/TAZ controlled melanoma growth and angiogenesis
Endothelial Epac1 facilitates YAP/TAZ controlled melanoma growth and angiogenesis
PRJNA1503447 | ENA
TranscriptomicsPodocyte Epac1 promotes glycolysis and protects against glomerulonephritis
The second messenger cyclic AMP (cAMP) is involved in many aspects of renal physiology and disease. Epac is an effector of cAMP and its pathophysiological role in the development of chronic kidney diseases (CKD) has yet to be determined. Here, we show that total Epac1 isoform genetic deletion does n...
ORGANISM(S): Mus musculus 
2024-06-10 | GSE237097 | GEO
TranscriptomicsEndothelial Epac1 facilitates YAP/TAZ controlled melanoma growth and angiogenesis
Mice were treated by 75 mg/kg BW/day tamoxifen intraperitoneally for 5 days to induce endothelial specific Epac1/Rapgef3 knockout. This knockout allows us to study the role of endothelial Epac1 in tumor angiogenesis in mice inoculated subcutaneously with B16-F10 melanoma. Tumour endothelial cells we...
ORGANISM(S): Mus musculus 
2026-09-30 | GSE341674 | GEO
TranscriptomicsGene expression profiling of wildtype vs. transgenic mice expressing the cardiac specific genetically encoded FRET biosensor Epac1-PLN
3’,5’-cyclic adenosine monophosphate (cAMP) is an ubiquitous second messenger which regulates multiple physiological functions by acting in distinct subcellular microdomains. Although several targeted cAMP biosensors have been developed and used in cell lines or neonatal cardiomyocytes, it is unclea...
ORGANISM(S): Mus musculus 
2015-03-02 | E-GEOD-65651 | biostudies-arrayexpress
UnknownEPAC1 enhances brown fat growth and beige adipogenesis.
Not available
S-EPMC10791580 | biostudies-literature
UnknownMembranes prime the RapGEF EPAC1 to transduce cAMP signaling.
Not available
S-EPMC10338474 | biostudies-literature
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