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ProteomicsHistone modifications during acute S-phase defects
Long-term perturbation of de novo chromatin assembly during DNA replication has profound effects on epigenome maintenance and cell fate. The early mechanistic origin of these functional defects is unknown. Here, we combine acute degradation of Chromatin Assembly Factor 1 (CAF-1), a key player in de ...
ORGANISM(S): Homo sapiens (Human) 
2024-11-14 | PXD050618 | Pride
Cell cycle Chromatin assembly Histone chaperones Epigenome stability Dna replication 
GenomicsSymmetric inheritance of parental histones governs epigenome maintenance and stem cell identity
Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity
PRJNA646113 | ENA
ProteomicsProfiling linkage-specific ubiquitin chain functions reveals a key role of K29-linked ubiquitylation in epigenome maintenance
Linkage-specific ubiquitin (Ub) chains dictate the functional outcome of many critical Ub-dependent signaling processes. However, the functions and targets of several poly-Ub topologies remain poorly understood due to a lack of tools for their specific detection and manipulation. To remedy this know...
ORGANISM(S): Homo sapiens (Human) 
2025-09-18 | PXD056493 | Pride
Ubiquitin  ubiquitin-proteasome system  k29-linked ubiquitylation  chromatin  epigenome 
ProteomicsFunctional landscape of ubiquitin linkages couples K29-linked ubiquitylation to epigenome integrity
Linkage-specific ubiquitin chains govern the outcome of numerous critical ubiquitin-dependent signaling processes. However, the targets and functional impacts of linkage-specific ubiquitin modifications remain incompletely understood, due to a paucity of tools for their specific detection and manipu...
ORGANISM(S): Homo sapiens (Human) 
2025-10-21 | PXD056564 | Pride
K29 Epigenome maintenance Trip12 Ubiquitylation 
ProteomicsInhibition of DNMT1 methyltransferase activity via glucose-regulated O-GlcNAcylation alters the epigenome
The DNA methyltransferase activity of DNMT1 is vital for genomic maintenance of DNA methylation. We report here that DNMT1 function is regulated by O-GlcNAcylation, a protein modification that is sensitive to glucose levels, and that elevated O-GlcNAcylation of DNMT1 from high glucose environment le...
ORGANISM(S): Homo sapiens (Human) 
2023-07-26 | PXD043031 | Pride
Metabolism O-glcnacylation Epigenetics Hyperglycemia 
GenomicsSymmetric inheritance of parental histones governs epigenome maintenance and stem cell identity [scRNA-seq]
Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity [scRNA-seq]
PRJNA803143 | ENA
GenomicsSymmetric inheritance of parental histones governs epigenome maintenance and stem cell identity [RNA-seq]
Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity [RNA-seq]
PRJNA646124 | ENA
GenomicsSymmetric inheritance of parental histones governs epigenome maintenance and stem cell identity [ChIP-seq]
Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity [ChIP-seq]
PRJNA646067 | ENA
GenomicsSymmetric inheritance of parental histones governs epigenome maintenance and stem cell identity [SCAR-seq]
Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity [SCAR-seq]
PRJNA646068 | ENA
TranscriptomicsHighly integrated epigenome maps in Arabidopsis - small RNA sequencing
Part of a set of highly integrated epigenome maps for Arabidopsis thaliana. Keywords: Illumina high-throughput small RNA sequencing Small RNA sequencing of wildtype Arabidopsis plants (Columbia-0), and met1, drm1 drm2 cmt3, and ros1 dml2 dml3 null mutants using the Illumina Genetic Analyzer.
ORGANISM(S): Arabidopsis thaliana 
2008-04-20 | E-GEOD-10967 | biostudies-arrayexpress
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